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Comparison of adults with insulin resistance (IR) in latent autoimmune diabetes versus IR in glutamic acid decarboxylase antibody-negative diabetes.

Overview of attention for article published in Annals of the Academy of Medicine Singapore, February 2014
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Title
Comparison of adults with insulin resistance (IR) in latent autoimmune diabetes versus IR in glutamic acid decarboxylase antibody-negative diabetes.
Published in
Annals of the Academy of Medicine Singapore, February 2014
DOI 10.47102/annals-acadmedsg.v43n2p107
Pubmed ID
Authors

Sameer D Salem, Riyadh Saif-Ali, Sekaran Muniandy, Zaid Al-Hamodi, Ikram S Ismail

Abstract

Introduction: Insulin resistance in latent autoimmune diabetes in adults (LADA) patients is controversial. The aim of this study was to evaluate insulin resistance and its related factors (metabolic syndrome parameters) among subjects with LADA and glutamic acid decarboxylase antibodies (GADA) negative diabetes, as well as the impact of these factors on insulin resistance. Materials and Methods: GADA levels were investigated in 1140 diabetic patients aged between 30 and 70 years. Insulin resistance and metabolic syndrome parameters were assessed in LADA and GAD-negative diabetic patients by general linear model. In addition, the impact of metabolic syndrome factors on insulin resistance was assessed in LADA and glutamic acid decarboxylase (GAD)-negative diabetic patients. Results: LADA was diagnosed in 33 subjects from 1140 Malaysian diabetic patients (prevalence = 2.9%). The results showed that LADA patients had higher insulin resistance and high density lipoprotein cholesterol (HDLc) (P = 0.003 and 0.00017 respectively) and lower body mass index (BMI) (P = 0.007) compared to GAD-negative diabetic patients. The HDLc was associated with decreased insulin resistance in LADA patients (P = 0.041), whereas HbA1c, triacylglycerides (TG) and waist were associated with increased insulin resistance in GAD-negative diabetic patients (P = 3.6×10⁻¹², 1.01×10⁻⁵ and 0.004 respectively). HbA1c was highly associated with decreasing β-cell function in both LADA (P = 0.009) and GAD-negative diabetic subjects (P = 2.2×10⁻²⁸). Conclusion: Insulin resistance is significantly higher in LADA than GAD-negative diabetic Malaysian subjects.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 29%
Lecturer 1 7%
Student > Bachelor 1 7%
Student > Doctoral Student 1 7%
Researcher 1 7%
Other 1 7%
Unknown 5 36%
Readers by discipline Count As %
Medicine and Dentistry 7 50%
Immunology and Microbiology 1 7%
Neuroscience 1 7%
Engineering 1 7%
Unknown 4 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2014.
All research outputs
#17,289,387
of 25,377,790 outputs
Outputs from Annals of the Academy of Medicine Singapore
#255
of 447 outputs
Outputs of similar age
#216,734
of 345,152 outputs
Outputs of similar age from Annals of the Academy of Medicine Singapore
#4
of 6 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 447 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,152 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.