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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
|
|---|---|
| Published in |
Nature, September 2011
|
| DOI | 10.1038/nature10405 |
| Pubmed ID | |
| Abstract |
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 29% |
| Japan | 3 | 9% |
| United Kingdom | 3 | 9% |
| Switzerland | 2 | 6% |
| Australia | 1 | 3% |
| Italy | 1 | 3% |
| France | 1 | 3% |
| Ireland | 1 | 3% |
| Netherlands | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 12 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 54% |
| Scientists | 12 | 34% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,311 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 2% |
| United Kingdom | 13 | <1% |
| Netherlands | 5 | <1% |
| Germany | 5 | <1% |
| Canada | 4 | <1% |
| France | 3 | <1% |
| Spain | 2 | <1% |
| Pakistan | 1 | <1% |
| Colombia | 1 | <1% |
| Other | 13 | <1% |
| Unknown | 1244 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 270 | 21% |
| Researcher | 254 | 19% |
| Student > Master | 123 | 9% |
| Student > Bachelor | 102 | 8% |
| Professor | 91 | 7% |
| Other | 277 | 21% |
| Unknown | 194 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 353 | 27% |
| Agricultural and Biological Sciences | 299 | 23% |
| Biochemistry, Genetics and Molecular Biology | 188 | 14% |
| Computer Science | 29 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 2% |
| Other | 169 | 13% |
| Unknown | 248 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#559,331
of 25,837,817 outputs
Outputs from Nature
#24,099
of 98,779 outputs
Outputs of similar age
#2,089
of 140,312 outputs
Outputs of similar age from Nature
#187
of 906 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,779 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,312 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 906 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.