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Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial

Overview of attention for article published in BMC Medical Research Methodology, June 2009
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Title
Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial
Published in
BMC Medical Research Methodology, June 2009
DOI 10.1186/1471-2288-9-41
Pubmed ID
Authors

M Diana van Die, Kerry M Bone, Henry G Burger, Helena J Teede

Abstract

Assumptions underlying placebo controlled trials include that the placebo effect impacts on all study arms equally, and that treatment effects are additional to the placebo effect. However, these assumptions have recently been challenged, and different mechanisms may potentially be operating in the placebo and treatment arms. The objective of the current study was to explore the nature of placebo versus pharmacological effects by comparing predictors of the placebo response with predictors of the treatment response in a randomised, placebo-controlled trial of a phytotherapeutic combination for the treatment of menopausal symptoms. A substantial placebo response was observed but no significant difference in efficacy between the two arms.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 13%
Student > Master 8 13%
Student > Bachelor 8 13%
Student > Ph. D. Student 7 11%
Student > Doctoral Student 4 6%
Other 12 19%
Unknown 15 24%
Readers by discipline Count As %
Medicine and Dentistry 19 31%
Agricultural and Biological Sciences 6 10%
Social Sciences 4 6%
Psychology 4 6%
Nursing and Health Professions 4 6%
Other 7 11%
Unknown 18 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2011.
All research outputs
#20,447,205
of 25,128,618 outputs
Outputs from BMC Medical Research Methodology
#1,931
of 2,243 outputs
Outputs of similar age
#109,571
of 118,524 outputs
Outputs of similar age from BMC Medical Research Methodology
#12
of 12 outputs
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