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Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

Overview of attention for article published in Kidney International, July 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
1 X user
patent
2 patents

Citations

dimensions_citation
337 Dimensions

Readers on

mendeley
167 Mendeley
citeulike
2 CiteULike
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Title
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy
Published in
Kidney International, July 2014
DOI 10.1038/ki.2014.271
Pubmed ID
Authors

Khurrum Shahzad, Fabian Bock, Wei Dong, Hongjie Wang, Stefan Kopf, Shrey Kohli, Moh'd Mohanad Al-Dabet, Satish Ranjan, Juliane Wolter, Christian Wacker, Ronald Biemann, Stoyan Stoyanov, Klaus Reymann, Peter Söderkvist, Olaf Groß, Vedat Schwenger, Sascha Pahernik, Peter P. Nawroth, Herman-Josef Gröne, Thati Madhusudhan, Berend Isermann

Abstract

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic nephropathy with inflammasome activation has recently been shown, but the pathophysiological relevance of this finding remains unknown. Within glomeruli, inflammasome activation was detected in endothelial cells and podocytes in diabetic humans and mice and in glucose-stressed glomerular endothelial cells and podocytes in vitro. Abolishing Nlrp3 or caspase-1 expression in bone marrow-derived cells fails to protect mice against diabetic nephropathy. Conversely, Nlrp3-deficient mice are protected against diabetic nephropathy despite transplantation of wild-type bone marrow. Pharmacological IL-1R antagonism prevented or even reversed diabetic nephropathy in mice. Mitochondrial reactive oxygen species (ROS) activate the Nlrp3 inflammasome in glucose or advanced glycation end product stressed podocytes. Inhibition of mitochondrial ROS prevents glomerular inflammasome activation and nephropathy in diabetic mice. Thus, mitochondrial ROS and Nlrp3-inflammasome activation in non-myeloid-derived cells aggravate diabetic nephropathy. Targeting the inflammasome may be a potential therapeutic approach to diabetic nephropathy.Kidney International advance online publication, 30 July 2014; doi:10.1038/ki.2014.271.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
China 1 <1%
Unknown 165 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 17%
Researcher 28 17%
Student > Bachelor 17 10%
Student > Master 15 9%
Student > Doctoral Student 9 5%
Other 26 16%
Unknown 44 26%
Readers by discipline Count As %
Medicine and Dentistry 32 19%
Biochemistry, Genetics and Molecular Biology 30 18%
Agricultural and Biological Sciences 22 13%
Immunology and Microbiology 8 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 4%
Other 17 10%
Unknown 51 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2023.
All research outputs
#1,472,308
of 25,374,917 outputs
Outputs from Kidney International
#470
of 7,406 outputs
Outputs of similar age
#14,430
of 239,660 outputs
Outputs of similar age from Kidney International
#2
of 51 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,406 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,660 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.