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Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases (the SCANDIUM trial): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, August 2014
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Title
Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases (the SCANDIUM trial): study protocol for a randomized controlled trial
Published in
Trials, August 2014
DOI 10.1186/1745-6215-15-317
Pubmed ID
Authors

Roger Olofsson, Lars Ny, Malin Sternby Eilard, Magnus Rizell, Christian Cahlin, Ulrika Stierner, Ulf Lönn, Johan Hansson, Ingrid Ljuslinder, Lotta Lundgren, Gustav Ullenhag, Jens Folke Kiilgaard, Jonas Nilsson, Per Lindnér

Abstract

Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumor, metastatic disease will ultimately develop in approximately 50% of patients, with the liver being the most common site for metastases. The median survival for patients with liver metastases is between 6 and 12 months, and no treatment has in randomized trials ever been shown to prolong survival. A previous phase II trial using isolated hepatic perfusion (IHP) has suggested a 14-month increase in overall survival compared with a historic control group consisting of the longest surviving patients in Sweden during the same time period (26 versus 12 months).

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Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 24%
Researcher 7 14%
Student > Bachelor 6 12%
Other 5 10%
Student > Postgraduate 3 6%
Other 7 14%
Unknown 9 18%
Readers by discipline Count As %
Medicine and Dentistry 26 53%
Biochemistry, Genetics and Molecular Biology 3 6%
Nursing and Health Professions 2 4%
Agricultural and Biological Sciences 2 4%
Neuroscience 2 4%
Other 2 4%
Unknown 12 24%