Title |
Therapeutic Options After Treatment Failure in Rheumatoid Arthritis or Spondyloarthritides
|
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Published in |
Advances in Therapy, August 2014
|
DOI | 10.1007/s12325-014-0142-8 |
Pubmed ID | |
Authors |
Marcello Govoni, Alessandra Bortoluzzi, Andrea Lo Monaco, Silvano Adami, Olga Addimanda, Cristian Caimmi, Salvatore De Vita, Clodoveo Ferri, Andreina Manfredi, Giovanni Orsolini, Niccolò Possemato, Luca Quartuccio, Carlo Salvarani, Alen Zabotti, Maurizio Rossini |
Abstract |
The prognosis for patients with rheumatoid arthritis or spondyloarthritides has improved dramatically due to earlier diagnosis, recognition of the need to treat early with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), alone or in combinations, the establishment of treatment targets, and the development of biological DMARDs (bDMARDs). Many patients are now able to achieve clinical remission or low disease activity with therapy, and reduce or eliminate systemic corticosteroid use. Guidelines recommend methotrexate as a first-line agent for the initial treatment of rheumatoid arthritis; however, a majority of patients will require a change of csDMARD or step up to combination therapy with the addition of another csDMARD or a bDMARD. However, treatment failure is common and switching to a different therapy may be required. The large number of available treatment options, combined with a lack of comparative data, makes the choice of a new therapy complex and often not evidence based. We summarize and discuss evidence to inform treatment decisions in patients who require a change in therapy, including baseline factors that may predict response to therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 22% |
Researcher | 7 | 17% |
Student > Bachelor | 6 | 15% |
Other | 3 | 7% |
Student > Master | 3 | 7% |
Other | 5 | 12% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 44% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
Arts and Humanities | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 3 | 7% |
Unknown | 10 | 24% |