| Title |
Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset
|
|---|---|
| Published in |
Brain Structure and Function, July 2014
|
| DOI | 10.1007/s00429-014-0853-2 |
| Pubmed ID | |
| Authors |
Tetsuya Sasaki, Hirosato Aoi, Tomofumi Oga, Ichiro Fujita, Noritaka Ichinohe |
| Abstract |
In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer III pyramidal cells in the medial prefrontal cortex (mPFC) of the common marmoset. The mPFC consists of several areas with distinct features in layer organization, histochemistry, connections, and, in humans, vulnerability to psychiatric disorders. We selected three areas for examination: granular dorsomedial prefrontal (area 8B/9), dysgranular ventromedial prefrontal (area 14r), and agranular anterior cingulate (area 24) cortices. Dendritic field areas, lengths, number of branching points, and total spine number reached a peak at 2-3 postnatal months in all three areas. However, the profiles of spine formation and pruning differed across the three areas with different degrees of granularity; the amount of spine loss from the peak to adulthood was less in areas 24 (33 %) and 14r (29 %) than in area 8B/9 (43 %). Disturbance of this modest spine pruning in the less granular cortical areas may lead to an excessive loss of spines reported for areas 24 and 14r of schizophrenic patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Spain | 1 | 2% |
| Japan | 1 | 2% |
| Unknown | 43 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 30% |
| Student > Ph. D. Student | 10 | 21% |
| Student > Master | 5 | 11% |
| Professor | 4 | 9% |
| Student > Bachelor | 3 | 6% |
| Other | 6 | 13% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 36% |
| Neuroscience | 13 | 28% |
| Medicine and Dentistry | 4 | 9% |
| Psychology | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 9 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2014.
All research outputs
#5,937,440
of 24,217,893 outputs
Outputs from Brain Structure and Function
#411
of 1,725 outputs
Outputs of similar age
#52,792
of 233,844 outputs
Outputs of similar age from Brain Structure and Function
#8
of 42 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,844 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.