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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vaccination with recombinant adenoviruses expressing Ebola virus glycoprotein elicits protection in the interferon alpha/beta receptor knock-out mouse
|
|---|---|
| Published in |
Virology, January 2014
|
| DOI | 10.1016/j.virol.2013.03.028 |
| Pubmed ID | |
| Authors |
Lyn M. O'Brien, Margaret G. Stokes, Stephen G. Lonsdale, David R. Maslowski, Sophie J. Smither, Mark S. Lever, Thomas R. Laws, Stuart D. Perkins |
| Abstract |
The resistance of adult immunocompetent mice to infection with ebolaviruses has led to the development of alternative small animal models that utilise immunodeficient mice, for example the interferon α/β receptor knock-out mouse (IFNR(-/-)). IFNR(-/-) mice have been shown to be susceptible to infection with ebolaviruses by multiple routes but it is not known if this murine model is suitable for testing therapeutics that rely on the generation of an immune response for efficacy. We have tested recombinant adenovirus vectors for their ability to protect IFNR(-/-) mice from challenge with Ebola virus and have analysed the humoral response generated after immunisation. The recombinant vaccines elicited good levels of protection in the knock-out mouse and the antibody response in IFNR(-/-) mice was similar to that observed in vaccinated wild-type mice. These results indicate that the IFNR(-/-) mouse is a relevant small animal model for studying ebolavirus-specific therapeutics. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Mexico | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Colombia | 1 | <1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Indonesia | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 102 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 20% |
| Student > Bachelor | 19 | 17% |
| Librarian | 14 | 13% |
| Student > Master | 13 | 12% |
| Student > Ph. D. Student | 11 | 10% |
| Other | 22 | 20% |
| Unknown | 8 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 28% |
| Medicine and Dentistry | 18 | 17% |
| Immunology and Microbiology | 9 | 8% |
| Nursing and Health Professions | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Other | 25 | 23% |
| Unknown | 14 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2014.
All research outputs
#2,863,902
of 25,374,647 outputs
Outputs from Virology
#406
of 9,498 outputs
Outputs of similar age
#32,653
of 320,967 outputs
Outputs of similar age from Virology
#6
of 50 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,498 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,967 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.