| Title |
The mammary cellular hierarchy and breast cancer
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2014
|
| DOI | 10.1007/s00018-014-1674-4 |
| Pubmed ID | |
| Authors |
Samantha R. Oakes, David Gallego-Ortega, Christopher J. Ormandy |
| Abstract |
Advances in the study of hematopoietic cell maturation have paved the way to a deeper understanding the stem and progenitor cellular hierarchy in the mammary gland. The mammary epithelium, unlike the hematopoietic cellular hierarchy, sits in a complex niche where communication between epithelial cells and signals from the systemic hormonal milieu, as well as from extra-cellular matrix, influence cell fate decisions and contribute to tissue homeostasis. We review the discovery, definition and regulation of the mammary cellular hierarchy and we describe the development of the concepts that have guided our investigations. We outline recent advances in in vivo lineage tracing that is now challenging many of our assumptions regarding the behavior of mammary stem cells, and we show how understanding these cellular lineages has altered our view of breast cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Unknown | 115 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 35% |
| Student > Master | 18 | 15% |
| Researcher | 13 | 11% |
| Student > Bachelor | 10 | 9% |
| Professor > Associate Professor | 6 | 5% |
| Other | 16 | 14% |
| Unknown | 13 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 32% |
| Biochemistry, Genetics and Molecular Biology | 35 | 30% |
| Medicine and Dentistry | 15 | 13% |
| Immunology and Microbiology | 4 | 3% |
| Veterinary Science and Veterinary Medicine | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 14 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2014.
All research outputs
#19,201,293
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,458
of 4,151 outputs
Outputs of similar age
#165,338
of 229,907 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#30
of 40 outputs
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