Title |
Common variants at five new loci associated with early-onset inflammatory bowel disease
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Published in |
Nature Genetics, November 2009
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DOI | 10.1038/ng.489 |
Pubmed ID | |
Authors |
Marcin Imielinski, Robert N Baldassano, Anne Griffiths, Richard K Russell, Vito Annese, Marla Dubinsky, Subra Kugathasan, Jonathan P Bradfield, Thomas D Walters, Patrick Sleiman, Cecilia E Kim, Aleixo Muise, Kai Wang, Joseph T Glessner, Shehzad Saeed, Haitao Zhang, Edward C Frackelton, Cuiping Hou, James H Flory, George Otieno, Rosetta M Chiavacci, Robert Grundmeier, Massimo Castro, Anna Latiano, Bruno Dallapiccola, Joanne Stempak, Debra J Abrams, Kent Taylor, Dermot McGovern, Melvin B Heyman, George D Ferry, Barbara Kirschner, Jessica Lee, Jonah Essers, Richard Grand, Michael Stephens, Arie Levine, David Piccoli, Johan Van Limbergen, Salvatore Cucchiara, Dimitri S Monos, Stephen L Guthery, Lee Denson, David C Wilson, Struan F A Grant, Mark Daly, Mark S Silverberg, Jack Satsangi, Hakon Hakonarson |
Abstract |
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Australia | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 2% |
Germany | 4 | 1% |
United Kingdom | 4 | 1% |
Sweden | 1 | <1% |
Canada | 1 | <1% |
Australia | 1 | <1% |
Unknown | 319 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 85 | 25% |
Student > Ph. D. Student | 79 | 23% |
Professor > Associate Professor | 23 | 7% |
Other | 20 | 6% |
Professor | 16 | 5% |
Other | 67 | 20% |
Unknown | 48 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 100 | 30% |
Medicine and Dentistry | 84 | 25% |
Biochemistry, Genetics and Molecular Biology | 40 | 12% |
Immunology and Microbiology | 19 | 6% |
Social Sciences | 7 | 2% |
Other | 30 | 9% |
Unknown | 58 | 17% |