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Chemical biology of genomic DNA: minimizing PCR bias

Overview of attention for article published in Chemical Communications, January 2014
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Title
Chemical biology of genomic DNA: minimizing PCR bias
Published in
Chemical Communications, January 2014
DOI 10.1039/c4cc05107f
Pubmed ID
Authors

Gordon R. McInroy, Eun-Ang Raiber, Shankar Balasubramanian

Abstract

The exquisite selectivity of chemical reactions enables the study of rare DNA bases. However, chemical modification of the genome can affect downstream analysis. We report a PCR bias caused by such modification, and exemplify a solution with the synthesis and characterization of a cleavable aldehyde-reactive biotinylation probe.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 5%
Russia 1 3%
Unknown 36 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Ph. D. Student 8 21%
Student > Master 4 10%
Professor 3 8%
Student > Doctoral Student 2 5%
Other 6 15%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 28%
Chemistry 10 26%
Biochemistry, Genetics and Molecular Biology 7 18%
Arts and Humanities 1 3%
Unspecified 1 3%
Other 2 5%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2014.
All research outputs
#15,303,896
of 22,760,687 outputs
Outputs from Chemical Communications
#14,675
of 21,262 outputs
Outputs of similar age
#190,022
of 305,282 outputs
Outputs of similar age from Chemical Communications
#608
of 956 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 21,262 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,282 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 956 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.