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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells
|
|---|---|
| Published in |
Nature Communications, August 2014
|
| DOI | 10.1038/ncomms5539 |
| Pubmed ID | |
| Authors |
Priyanka Sathe, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J. Vandenberg, Lucille C. Rankin, Lisa A. Mielke, Ingela Vikstrom, Tatiana B. Kolesnik, Sandra E. Nicholson, Eric Vivier, Mark J. Smyth, Stephen L. Nutt, Stefan P. Glaser, Andreas Strasser, Gabrielle T. Belz, Sebastian Carotta, Nicholas D. Huntington |
| Abstract |
The cytokine IL-15 is required for natural killer (NK) cell homeostasis; however, the intrinsic mechanism governing this requirement remains unexplored. Here we identify the absolute requirement for myeloid cell leukaemia sequence-1 (Mcl1) in the sustained survival of NK cells in vivo. Mcl1 is highly expressed in NK cells and regulated by IL-15 in a dose-dependent manner via STAT5 phosphorylation and subsequent binding to the 3'-UTR of Mcl1. Specific deletion of Mcl1 in NK cells results in the absolute loss of NK cells from all tissues owing to a failure to antagonize pro-apoptotic proteins in the outer mitochondrial membrane. This NK lymphopenia results in mice succumbing to multiorgan melanoma metastases, being permissive to allogeneic transplantation and being resistant to toxic shock following polymicrobial sepsis challenge. These results clearly demonstrate a non-redundant pathway linking IL-15 to Mcl1 in the maintenance of NK cells and innate immune responses in vivo. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 20% |
| United States | 1 | 10% |
| Unknown | 7 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Science communicators (journalists, bloggers, editors) | 2 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Austria | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 112 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 23% |
| Researcher | 18 | 16% |
| Student > Master | 16 | 14% |
| Student > Doctoral Student | 9 | 8% |
| Other | 7 | 6% |
| Other | 18 | 16% |
| Unknown | 20 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 29 | 25% |
| Agricultural and Biological Sciences | 25 | 22% |
| Biochemistry, Genetics and Molecular Biology | 19 | 17% |
| Medicine and Dentistry | 16 | 14% |
| Engineering | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2020.
All research outputs
#1,561,628
of 22,760,687 outputs
Outputs from Nature Communications
#20,826
of 46,872 outputs
Outputs of similar age
#17,024
of 231,195 outputs
Outputs of similar age from Nature Communications
#261
of 676 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,872 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,195 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 676 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.