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Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

Overview of attention for article published in Nature, December 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

blogs
1 blog
twitter
2 X users
patent
3 patents
facebook
2 Facebook pages
wikipedia
36 Wikipedia pages
q&a
1 Q&A thread

Citations

dimensions_citation
792 Dimensions

Readers on

mendeley
1176 Mendeley
citeulike
27 CiteULike
connotea
2 Connotea
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Title
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Published in
Nature, December 2010
DOI 10.1038/nature09725
Pubmed ID
Authors

Peter V. Kharchenko, Artyom A. Alekseyenko, Yuri B. Schwartz, Aki Minoda, Nicole C. Riddle, Jason Ernst, Peter J. Sabo, Erica Larschan, Andrey A. Gorchakov, Tingting Gu, Daniela Linder-Basso, Annette Plachetka, Gregory Shanower, Michael Y. Tolstorukov, Lovelace J. Luquette, Ruibin Xi, Youngsook L. Jung, Richard W. Park, Eric P. Bishop, Theresa K. Canfield, Richard Sandstrom, Robert E. Thurman, David M. MacAlpine, John A. Stamatoyannopoulos, Manolis Kellis, Sarah C. R. Elgin, Mitzi I. Kuroda, Vincenzo Pirrotta, Gary H. Karpen, Peter J. Park

Abstract

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,176 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 46 4%
United Kingdom 15 1%
Spain 11 <1%
France 8 <1%
Germany 6 <1%
Japan 6 <1%
Sweden 3 <1%
Austria 3 <1%
Brazil 3 <1%
Other 31 3%
Unknown 1044 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 341 29%
Researcher 309 26%
Student > Master 94 8%
Professor > Associate Professor 78 7%
Student > Bachelor 68 6%
Other 177 15%
Unknown 109 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 676 57%
Biochemistry, Genetics and Molecular Biology 252 21%
Computer Science 36 3%
Medicine and Dentistry 26 2%
Neuroscience 16 1%
Other 48 4%
Unknown 122 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2024.
All research outputs
#1,586,400
of 23,306,612 outputs
Outputs from Nature
#37,728
of 92,051 outputs
Outputs of similar age
#8,749
of 184,243 outputs
Outputs of similar age from Nature
#225
of 630 outputs
Altmetric has tracked 23,306,612 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,051 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,243 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 630 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.