| Title |
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, September 2012
|
| DOI | 10.1186/1745-6215-13-177 |
| Pubmed ID | |
| Authors |
Mayur B Patel, John W McKenna, JoAnn M Alvarez, Ayaka Sugiura, Judith M Jenkins, Oscar D Guillamondegui, Pratik P Pandharipande |
| Abstract |
Severe TBI, defined as a Glasgow Coma Scale ≤ 8, increases intracranial pressure and activates the sympathetic nervous system. Sympathetic hyperactivity after TBI manifests as catecholamine excess, hypertension, abnormal heart rate variability, and agitation, and is associated with poor neuropsychological outcome. Propranolol and clonidine are centrally acting drugs that may decrease sympathetic outflow, brain edema, and agitation. However, there is no prospective randomized evidence available demonstrating the feasibility, outcome benefits, and safety for adrenergic blockade after TBI. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 202 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 15% |
| Student > Master | 27 | 13% |
| Student > Doctoral Student | 21 | 10% |
| Other | 17 | 8% |
| Student > Bachelor | 17 | 8% |
| Other | 42 | 20% |
| Unknown | 54 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 82 | 39% |
| Psychology | 16 | 8% |
| Nursing and Health Professions | 11 | 5% |
| Neuroscience | 11 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Other | 23 | 11% |
| Unknown | 59 | 28% |