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Placental Lipases in Pregnancies Complicated by Gestational Diabetes Mellitus (GDM)

Overview of attention for article published in PLOS ONE, August 2014
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Title
Placental Lipases in Pregnancies Complicated by Gestational Diabetes Mellitus (GDM)
Published in
PLOS ONE, August 2014
DOI 10.1371/journal.pone.0104826
Pubmed ID
Authors

Helen L. Barrett, Marta H. Kubala, Katherin Scholz Romero, Kerina J. Denny, Trent M. Woodruff, H. David McIntyre, Leonie K. Callaway, Marloes Dekker Nitert

Abstract

Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large for gestational age with a higher percentage body fat. Elevated maternal lipids may contribute to this. Placental lipases such as lipoprotein lipase (LPL), endothelial lipase (EL) and hormone sensitive lipase (HSL) are involved in transferring lipids from mother to fetus. Previous studies of expression of these lipases in placentae in women with diabetes in pregnancy have reported divergent results. Intracellular lipases such as adipose triglyceride lipase (ATGL), and HSL are central to lipid droplet metabolism. The activities of these lipases are both influenced by Perilipin 1, and ATGL is also activated by a co-factor comparative gene identification-58 (CGI-58) and inhibited by G0/G1 switch gene 2 (GS02). None of these modifying factors or ATGL have been examined previously in placenta. The purpose of this study was therefore to examine the expression of ATGL, HSL, LPL, EL, as well as Perilipin 1, GS02 and CGI-58 in term pregnancies complicated by GDM. mRNA and protein expression of the lipases were measured in placentae from 17 women with GDM and 17 normoglycaemic pregnancies, matched for maternal BMI and gestational age of delivery. ATGL mRNA expression was increased and HSL mRNA expression reduced in placentae from GDM although there was no differences in protein expression of any of the lipases. All lipases were localised to trophoblasts and endothelial cells. The expression of Perilipin 1 and CGI-58 mRNA was increased and GS02 not altered in GDM. These results suggest that there is no difference in expression in these four lipases between GDM and normoglycaemic placentae, and therefore altered lipid transfer via these lipases does not contribute to large for gestational age in infants of women with GDM.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 24%
Student > Master 8 15%
Researcher 7 13%
Other 5 9%
Student > Bachelor 4 7%
Other 10 18%
Unknown 8 15%
Readers by discipline Count As %
Medicine and Dentistry 17 31%
Biochemistry, Genetics and Molecular Biology 10 18%
Agricultural and Biological Sciences 6 11%
Nursing and Health Professions 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 6 11%
Unknown 12 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2014.
All research outputs
#20,234,388
of 22,760,687 outputs
Outputs from PLOS ONE
#173,329
of 194,199 outputs
Outputs of similar age
#194,276
of 231,106 outputs
Outputs of similar age from PLOS ONE
#3,964
of 4,726 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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