Title |
A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity
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Published in |
AIDS, October 2014
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DOI | 10.1097/qad.0000000000000423 |
Pubmed ID | |
Authors |
Cinzia Giagulli, Francesca Caccuri, Francesca Cignarella, Vassilios Lougaris, Debora Martorelli, Antonella Bugatti, Marco Rusnati, Riccardo Dolcetti, Massimiliano Vitali, Alessandro Plebani, Simona Fiorentini, Arnaldo Caruso |
Abstract |
Monocyte inflammatory processes are fundamental events in AIDS pathogenesis. HIV-1 matrix protein p17, released from infected cells, was found to exert an interleukin (IL)-8 chemokine-like activity on human monocytes, promoting their trafficking and sustaining inflammatory processes, after binding to CXCR1. A haplotype of the CXCR1 gene (CXCR1_300_142) has been associated with slow HIV disease progression. Here, we determine how CXCR1 genetic variations impact on p17 biological activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 3 | 18% |
Student > Ph. D. Student | 2 | 12% |
Student > Bachelor | 1 | 6% |
Student > Master | 1 | 6% |
Researcher | 1 | 6% |
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Unknown | 8 | 47% |
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Medicine and Dentistry | 3 | 18% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Immunology and Microbiology | 2 | 12% |
Agricultural and Biological Sciences | 1 | 6% |
Unknown | 9 | 53% |