Title |
Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry
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Published in |
Molecular Autism, March 2010
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DOI | 10.1186/2040-2392-1-7 |
Pubmed ID | |
Authors |
Inês Sousa, Taane G Clark, Richard Holt, Alistair T Pagnamenta, Erik J Mulder, Ruud B Minderaa, Anthony J Bailey, Agatino Battaglia, Sabine M Klauck, Fritz Poustka, Anthony P Monaco, International Molecular Genetic Study of Autism Consortium (IMGSAC) |
Abstract |
Autism spectrum disorders (ASDs) are a group of highly heritable neurodevelopmental disorders which are characteristically comprised of impairments in social interaction, communication and restricted interests/behaviours. Several cell adhesion transmembrane leucine-rich repeat (LRR) proteins are highly expressed in the nervous system and are thought to be key regulators of its development. Here we present an association study analysing the roles of four promising candidate genes - LRRTM1 (2p), LRRTM3 (10q), LRRN1 (3p) and LRRN3 (7q) - in order to identify common genetic risk factors underlying ASDs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
India | 1 | 1% |
Unknown | 83 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 18 | 21% |
Researcher | 17 | 20% |
Student > Ph. D. Student | 14 | 16% |
Student > Bachelor | 9 | 11% |
Professor | 5 | 6% |
Other | 17 | 20% |
Unknown | 5 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 29% |
Medicine and Dentistry | 13 | 15% |
Biochemistry, Genetics and Molecular Biology | 13 | 15% |
Neuroscience | 9 | 11% |
Psychology | 6 | 7% |
Other | 9 | 11% |
Unknown | 10 | 12% |