| Title |
Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
|
|---|---|
| Published in |
The Journal of Physiological Sciences, March 2012
|
| DOI | 10.1007/s12576-012-0204-0 |
| Pubmed ID | |
| Authors |
Hidenobu Fukumura, Motohiko Sato, Kyouhei Kezuka, Itaru Sato, Xianfeng Feng, Satoshi Okumura, Takayuki Fujita, Utako Yokoyama, Haruki Eguchi, Yoshihiro Ishikawa, Tomoyuki Saito |
| Abstract |
Cellular reactive oxygen species (ROS) production is increased by both temperature and anticancer drugs. Antioxidants are known to suppress ROS production while cancer patients may take them as dietary supplement during chemotherapy and hyperthermic therapy. We examined changes in ROS production in prostate cancer cells in the presence of various anticancer drugs and antioxidants at different temperatures. ROS production was increased with temperature in cancer cells, but not in normal cells; this increase was potently inhibited by ascorbic acid. ROS production was also increased in the presence of some anticancer drugs, such as vinblastine, but not by others. Dietary antioxidant supplements, such as β-carotene, showed variable effects. Ascorbic acid potently inhibited ROS production, even in the presence of anticancer drugs, while β-carotene showed no inhibition. Accordingly, our results suggest that cancer patients should carefully choose antioxidants during their cancer chemotherapy and/or hyperthermic therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 16% |
| Student > Master | 5 | 10% |
| Student > Bachelor | 5 | 10% |
| Other | 4 | 8% |
| Researcher | 4 | 8% |
| Other | 9 | 18% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Agricultural and Biological Sciences | 7 | 14% |
| Chemistry | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 8 | 16% |
| Unknown | 13 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2020.
All research outputs
#3,954,928
of 23,975,976 outputs
Outputs from The Journal of Physiological Sciences
#34
of 321 outputs
Outputs of similar age
#24,585
of 158,907 outputs
Outputs of similar age from The Journal of Physiological Sciences
#1
of 5 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 321 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,907 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them