| Title |
Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny
|
|---|---|
| Published in |
Neuroscience Bulletin, August 2014
|
| DOI | 10.1007/s12264-014-1453-5 |
| Pubmed ID | |
| Authors |
Andrew J. Crowther, Juan Song |
| Abstract |
Adult neural stem cells (NSCs) reside in a restricted microenvironment, where their development is controlled by subtle and presently underexplored cues. This raises a significant question: what instructions must be provided by this supporting niche to regulate NSC development and functions? Signaling from the niche is proposed to control many aspects of NSC behavior, including balancing the quiescence and proliferation of NSCs, determining the cell division mode (symmetric versus asymmetric), and preventing premature depletion of stem cells to maintain neurogenesis throughout life. Interactions between neurogenic niches and NSCs also govern the homeostatic regulation of adult neurogenesis under diverse physiological, environmental, and pathological conditions. An important implication from revisiting many previously-identifi ed regulatory factors is that most of them (e.g., the antidepressant fluoxetine and exercise) affect gross neurogenesis by acting downstream of NSCs at the level of intermediate progenitors and neuroblasts, while leaving the NSC pool unaffected. Therefore, it is critically important to address how various niche components, signaling pathways, and environmental stimuli differentially regulate distinct stages of adult neurogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 3% |
| Morocco | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 66 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 31% |
| Researcher | 13 | 19% |
| Student > Master | 10 | 14% |
| Student > Bachelor | 8 | 11% |
| Professor > Associate Professor | 4 | 6% |
| Other | 8 | 11% |
| Unknown | 5 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 29 | 41% |
| Agricultural and Biological Sciences | 17 | 24% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Medicine and Dentistry | 4 | 6% |
| Immunology and Microbiology | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 9 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2014.
All research outputs
#7,134,005
of 22,760,687 outputs
Outputs from Neuroscience Bulletin
#220
of 762 outputs
Outputs of similar age
#69,299
of 229,519 outputs
Outputs of similar age from Neuroscience Bulletin
#2
of 8 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 762 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.