| Title |
Disturbed Th17/Treg balance in patients with rheumatoid arthritis
|
|---|---|
| Published in |
Rheumatology International, August 2011
|
| DOI | 10.1007/s00296-011-1984-x |
| Pubmed ID | |
| Authors |
Qian Niu, Bei Cai, Zhuo-chun Huang, Yun-ying Shi, Lan-lan Wang |
| Abstract |
Proinflammatory Th17 cells and CD4(+)CD25(+) regulatory T (Treg) cells are two newly identified T lymphocyte subsets, which have opposite effects on autoimmunity and inflammation. To assess the Th17/Treg pattern and cytokine microenvironment in peripheral blood of patients with RA, we included 66 RA patients and 20 healthy volunteers. Of all these subjects, peripheral Th17 and Treg frequencies were analyzed by flow cytometry (FCM) and the plasma levels of interleukin (IL)-17, 23, 6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1 were detected by ELISA. The results demonstrated that RA patients revealed an obvious increase in peripheral Th17 frequencies and levels of Th17-related cytokines (IL-17, IL-23, IL-6, TNF-α) while a significant decrease in Treg frequencies and Treg-related cytokine (TGF-β1) levels when compared with healthy people. Our study indicated that development of RA is associated with peripheral Th17/Treg imbalance and characterized by a proinflammatory cytokine microenvironment, which supports continuing generation of Th17 cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 96 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Researcher | 15 | 15% |
| Student > Master | 12 | 12% |
| Student > Bachelor | 9 | 9% |
| Student > Doctoral Student | 7 | 7% |
| Other | 15 | 15% |
| Unknown | 20 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 18 | 19% |
| Medicine and Dentistry | 17 | 18% |
| Biochemistry, Genetics and Molecular Biology | 15 | 15% |
| Agricultural and Biological Sciences | 14 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 25 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2011.
All research outputs
#18,295,723
of 22,651,245 outputs
Outputs from Rheumatology International
#1,782
of 2,170 outputs
Outputs of similar age
#99,068
of 119,616 outputs
Outputs of similar age from Rheumatology International
#24
of 33 outputs
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