| Title |
Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro
|
|---|---|
| Published in |
Bulletin of Experimental Biology and Medicine, August 2014
|
| DOI | 10.1007/s10517-014-2595-9 |
| Pubmed ID | |
| Authors |
A. V. Snigireva, V. V. Vrublevskaya, Yu. Yu. Skarga, Yu. V. Evdokimovskaya, O. S. Morenkov |
| Abstract |
We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32% (p<0.05). Polyclonal antibodies to Hsp90 blocked the Hsp90-dependent stimulation of cell invasion, which indicates specifi city of the stimulating effect of extracellular Hsp90 on tumor cell invasion. Hence, extracellular Hsp90 can be considered as a promising molecular target, because its inhibition can suppress invasion and metastasizing of tumor cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 30% |
| Student > Master | 2 | 20% |
| Student > Bachelor | 1 | 10% |
| Other | 1 | 10% |
| Student > Doctoral Student | 1 | 10% |
| Other | 1 | 10% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 60% |
| Agricultural and Biological Sciences | 3 | 30% |
| Unknown | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2014.
All research outputs
#16,454,538
of 24,217,893 outputs
Outputs from Bulletin of Experimental Biology and Medicine
#597
of 1,357 outputs
Outputs of similar age
#138,275
of 235,558 outputs
Outputs of similar age from Bulletin of Experimental Biology and Medicine
#1
of 11 outputs
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So far Altmetric has tracked 1,357 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.