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Attention Score in Context
| Title |
A smart upconversion-based mesoporous silica nanotheranostic system for synergetic chemo-/radio-/photodynamic therapy and simultaneous MR/UCL imaging
|
|---|---|
| Published in |
Clinical Materials, August 2014
|
| DOI | 10.1016/j.biomaterials.2014.07.024 |
| Pubmed ID | |
| Authors |
Wenpei Fan, Bo Shen, Wenbo Bu, Feng Chen, Qianjun He, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Dalong Ni, Jianan Liu, Jianlin Shi |
| Abstract |
To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may provide a more advanced way for the efficient theranostics of cancer. In this study, sub-80 nm rattle-structured multifunctional Gd-UCNPs core/mesoporous silica shell nanotheranostics (UCMSNs) were successfully constructed for the co-delivery of a radio-/photo-sensitizer hematoporphyrin (HP) and a radiosensitizer/chemodrug docetaxel (Dtxl). Upon NIR excitation and X-ray irradiation, the complete tumor elimination has been achieved by the synergetic chemo-/radio-/photodynamic tri-modal therapy under the assistance of simultaneous magnetic/upconversion luminescent (MR/UCL) bimodal imaging. To the best of our knowledge, this study is the first example of achieving tri-modal synergetic therapy in one single nanotheranostic system, and we anticipate that it may serve as a particularly useful platform for the clinical diagnosis and efficient treatment of cancer from bench to beside. |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 97 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 22% |
| Student > Master | 15 | 15% |
| Student > Bachelor | 11 | 11% |
| Researcher | 10 | 10% |
| Unspecified | 6 | 6% |
| Other | 17 | 17% |
| Unknown | 18 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 24 | 24% |
| Materials Science | 11 | 11% |
| Medicine and Dentistry | 10 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Unspecified | 6 | 6% |
| Other | 19 | 19% |
| Unknown | 23 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2019.
All research outputs
#2,330,095
of 25,374,917 outputs
Outputs from Clinical Materials
#454
of 10,751 outputs
Outputs of similar age
#23,088
of 241,586 outputs
Outputs of similar age from Clinical Materials
#6
of 100 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,751 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,586 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.