| Title |
Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy
|
|---|---|
| Published in |
Medical Oncology, September 2017
|
| DOI | 10.1007/s12032-017-1039-6 |
| Pubmed ID | |
| Authors |
Li Li, Ping Tang, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Yiyao Liu |
| Abstract |
Notch signaling pathway is evolutionarily conserved in mammals, which plays an important role in cell development and differentiation. In recent years, increasing evidence has shown that aberrant activation of Notch is associated with tumor process. Aberrant activation of Notch signaling pathway has been found in many different solid tumors can induce cell proliferation, metastasis and epithelial-mesenchymal transition. Notch receptor and its ligand are both single transmembrane protein, and Notch is activated when it binds to the Notch ligand of neighbor cells. The signal transduction of Notch signaling pathway is only between cells that are in contact with each other, which is independent of second messengers. Thus, Notch needs to cross talk with other signaling pathways, including PI3K/AKT, NF-κB, integrin and miRNAs, to precisely regulate cell fate. In this review, we summarize the roles of Notch signaling pathway in tumor metastasis and its regulatory mechanisms and discuss the current treatment strategies targeting Notch signal pathway. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 126 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 13% |
| Student > Ph. D. Student | 16 | 13% |
| Student > Master | 13 | 10% |
| Researcher | 12 | 10% |
| Student > Postgraduate | 8 | 6% |
| Other | 13 | 10% |
| Unknown | 47 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 32 | 25% |
| Medicine and Dentistry | 14 | 11% |
| Agricultural and Biological Sciences | 8 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Chemistry | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 54 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2022.
All research outputs
#2,908,213
of 23,002,898 outputs
Outputs from Medical Oncology
#40
of 1,301 outputs
Outputs of similar age
#51,735
of 289,792 outputs
Outputs of similar age from Medical Oncology
#2
of 16 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,301 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.