Title |
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen
|
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Published in |
Phytomedicine, April 2000
|
DOI | 10.1016/s0944-7113(00)80078-1 |
Pubmed ID | |
Authors |
A.A. Spasov, G.K. Wikman, V.B. Mandrikov, I.A. Mironova, V.V. Neumoin |
Abstract |
The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 18% |
Canada | 1 | 9% |
United States | 1 | 9% |
Spain | 1 | 9% |
Unknown | 6 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 91% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
Australia | 1 | <1% |
Colombia | 1 | <1% |
Canada | 1 | <1% |
Poland | 1 | <1% |
Unknown | 221 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 57 | 25% |
Student > Master | 41 | 18% |
Researcher | 29 | 13% |
Other | 17 | 7% |
Student > Ph. D. Student | 12 | 5% |
Other | 36 | 16% |
Unknown | 38 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 62 | 27% |
Agricultural and Biological Sciences | 32 | 14% |
Nursing and Health Professions | 16 | 7% |
Biochemistry, Genetics and Molecular Biology | 16 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 6% |
Other | 44 | 19% |
Unknown | 46 | 20% |