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Pyramidal Cells Make Specific Connections onto Smooth (GABAergic) Neurons in Mouse Visual Cortex

Overview of attention for article published in PLoS Biology, August 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
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16 X users

Citations

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28 Dimensions

Readers on

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116 Mendeley
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4 CiteULike
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Title
Pyramidal Cells Make Specific Connections onto Smooth (GABAergic) Neurons in Mouse Visual Cortex
Published in
PLoS Biology, August 2014
DOI 10.1371/journal.pbio.1001932
Pubmed ID
Authors

Rita Bopp, Nuno Maçarico da Costa, Björn M. Kampa, Kevan A. C. Martin, Morgane M. Roth

Abstract

One of the hallmarks of neocortical circuits is the predominance of recurrent excitation between pyramidal neurons, which is balanced by recurrent inhibition from smooth GABAergic neurons. It has been previously described that in layer 2/3 of primary visual cortex (V1) of cat and monkey, pyramidal cells filled with horseradish peroxidase connect approximately in proportion to the spiny (excitatory, 95% and 81%, respectively) and smooth (GABAergic, 5% and 19%, respectively) dendrites found in the neuropil. By contrast, a recent ultrastructural study of V1 in a single mouse found that smooth neurons formed 51% of the targets of the superficial layer pyramidal cells. This suggests that either the neuropil of this particular mouse V1 had a dramatically different composition to that of V1 in cat and monkey, or that smooth neurons were specifically targeted by the pyramidal cells in that mouse. We tested these hypotheses by examining similar cells filled with biocytin in a sample of five mice. We found that the average composition of the neuropil in V1 of these mice was similar to that described for cat and monkey V1, but that the superficial layer pyramidal cells do form proportionately more synapses with smooth dendrites than the equivalent neurons in cat or monkey. These distributions may underlie the distinct differences in functional architecture of V1 between rodent and higher mammals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 3 3%
Switzerland 2 2%
Germany 2 2%
United States 2 2%
United Kingdom 1 <1%
Netherlands 1 <1%
Belarus 1 <1%
Australia 1 <1%
Unknown 103 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 26%
Student > Ph. D. Student 28 24%
Student > Master 10 9%
Professor 8 7%
Professor > Associate Professor 8 7%
Other 21 18%
Unknown 11 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 41 35%
Neuroscience 36 31%
Medicine and Dentistry 6 5%
Physics and Astronomy 5 4%
Computer Science 5 4%
Other 12 10%
Unknown 11 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2014.
All research outputs
#2,143,605
of 25,394,764 outputs
Outputs from PLoS Biology
#3,169
of 8,848 outputs
Outputs of similar age
#21,536
of 247,248 outputs
Outputs of similar age from PLoS Biology
#41
of 61 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,848 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.