Title |
Concise Review: Understanding Clonal Dynamics in Homeostasis and Injury Through Multicolor Lineage Tracing
|
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Published in |
Stem Cells, November 2014
|
DOI | 10.1002/stem.1804 |
Pubmed ID | |
Authors |
Edwige Roy, Zoltan Neufeld, Jean Livet, Kiarash Khosrotehrani |
Abstract |
Lineage tracing is an essential tool to study stem cell fate. Although traditional lineage tracing techniques have considerably advanced our understanding of stem cell behaviour, they pose significant limitations for identification and longitudinal tracking of the progeny of individual stem cells, to compare their behaviours. This is of importance given the well-established heterogeneity among stem cells both in terms of potentialities and proliferative capacities. The recent development of multicolour genetic reporters addressable to specific cell populations largely overcomes these issues. These new "rainbow" technologies provide increased resolution in clonal identification and offer the possibility to study the relative distribution, contacts, tiled arrangement and competitive interactions among cells or groups of cells of the same type. Stem Cells 2014. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 92 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 23% |
Researcher | 18 | 20% |
Student > Bachelor | 10 | 11% |
Student > Master | 9 | 10% |
Professor > Associate Professor | 6 | 7% |
Other | 14 | 15% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 28 | 30% |
Agricultural and Biological Sciences | 28 | 30% |
Medicine and Dentistry | 9 | 10% |
Neuroscience | 3 | 3% |
Chemistry | 2 | 2% |
Other | 7 | 8% |
Unknown | 15 | 16% |