| Title |
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
|
|---|---|
| Published in |
BMC Neurology, March 2006
|
| DOI | 10.1186/1471-2377-6-12 |
| Pubmed ID | |
| Authors |
Yiangos Yiangou, Paul Facer, Pascal Durrenberger, Iain P Chessell, Alan Naylor, Chas Bountra, Richard R Banati, Praveen Anand |
| Abstract |
While multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are primarily inflammatory and degenerative disorders respectively, there is increasing evidence for shared cellular mechanisms that may affect disease progression, particularly glial responses. Cyclooxygenase 2 (COX-2) inhibition prolongs survival and cannabinoids ameliorate progression of clinical disease in animal models of ALS and MS respectively, but the mechanism is uncertain. Therefore, three key molecules known to be expressed in activated microglial cells/macrophages, COX-2, CB2 and P2X7, which plays a role in inflammatory cascades, were studied in MS and ALS post-mortem human spinal cord. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 283 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Germany | 2 | <1% |
| Hungary | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 276 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 19% |
| Researcher | 50 | 18% |
| Student > Master | 35 | 12% |
| Student > Bachelor | 29 | 10% |
| Professor > Associate Professor | 15 | 5% |
| Other | 48 | 17% |
| Unknown | 51 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 55 | 19% |
| Agricultural and Biological Sciences | 45 | 16% |
| Medicine and Dentistry | 40 | 14% |
| Biochemistry, Genetics and Molecular Biology | 35 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 5% |
| Other | 35 | 12% |
| Unknown | 59 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2017.
All research outputs
#6,941,350
of 22,760,687 outputs
Outputs from BMC Neurology
#778
of 2,428 outputs
Outputs of similar age
#23,360
of 71,412 outputs
Outputs of similar age from BMC Neurology
#1
of 8 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,428 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,412 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them