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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
|
|---|---|
| Published in |
Cancer Cell, August 2014
|
| DOI | 10.1016/j.ccr.2014.07.007 |
| Pubmed ID | |
| Authors |
Jacob R. Haling, Jawahar Sudhamsu, Ivana Yen, Steve Sideris, Wendy Sandoval, Wilson Phung, Brandon J. Bravo, Anthony M. Giannetti, Ariana Peck, Alexandre Masselot, Tony Morales, Darin Smith, Barbara J. Brandhuber, Sarah G. Hymowitz, Shiva Malek |
| Abstract |
Numerous oncogenic mutations occur within the BRAF kinase domain (BRAF(KD)). Here we show that stable BRAF-MEK1 complexes are enriched in BRAF(WT) and KRAS mutant (MT) cells but not in BRAF(MT) cells. The crystal structure of the BRAF(KD) in a complex with MEK1 reveals a face-to-face dimer sensitive to MEK1 phosphorylation but insensitive to BRAF dimerization. Structure-guided studies reveal that oncogenic BRAF mutations function by bypassing the requirement for BRAF dimerization for activity or weakening the interaction with MEK1. Finally, we show that conformation-specific BRAF inhibitors can sequester a dormant BRAF-MEK1 complex resulting in pathway inhibition. Taken together, these findings reveal a regulatory role for BRAF in the MAPK pathway independent of its kinase activity but dependent on interaction with MEK. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 53% |
| Belgium | 1 | 7% |
| United Kingdom | 1 | 7% |
| France | 1 | 7% |
| Unknown | 4 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 93% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 297 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 85 | 28% |
| Researcher | 56 | 18% |
| Student > Bachelor | 33 | 11% |
| Student > Master | 23 | 8% |
| Student > Postgraduate | 10 | 3% |
| Other | 30 | 10% |
| Unknown | 66 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 91 | 30% |
| Agricultural and Biological Sciences | 76 | 25% |
| Chemistry | 26 | 9% |
| Medicine and Dentistry | 21 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 3% |
| Other | 9 | 3% |
| Unknown | 72 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2023.
All research outputs
#1,767,919
of 25,374,647 outputs
Outputs from Cancer Cell
#1,183
of 3,149 outputs
Outputs of similar age
#17,831
of 247,555 outputs
Outputs of similar age from Cancer Cell
#12
of 45 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,555 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.