| Title |
MeCP2: multifaceted roles in gene regulation and neural development
|
|---|---|
| Published in |
Neuroscience Bulletin, August 2014
|
| DOI | 10.1007/s12264-014-1452-6 |
| Pubmed ID | |
| Authors |
Tian-Lin Cheng, Zilong Qiu |
| Abstract |
Methyl-CpG-binding protein 2 (MeCP2) is a classic methylated-DNA-binding protein, dysfunctions of which lead to various neurodevelopmental disorders such as Rett syndrome and autism spectrum disorder. Initially recognized as a transcriptional repressor, MeCP2 has been studied extensively and its functions have been expanded dramatically in the past two decades. Recently, it was found to be involved in gene regulation at the post-transcriptional level. MeCP2 represses nuclear microRNA processing by interacting directly with the Drosha/DGCR8 complex. In addition to its multifaceted functions, MeCP2 is remarkably modulated by posttranslational modifications such as phosphorylation, SUMOylation, and acetylation, providing more regulatory dimensions to its functions. The role of MeCP2 in the central nervous system has been studied extensively, from neurons to glia. Future investigations combining molecular, cellular, and physiological methods are necessary for defining the roles of MeCP2 in the brain and developing efficient treatments for MeCP2-related brain disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 87 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 25% |
| Student > Bachelor | 13 | 15% |
| Student > Master | 12 | 14% |
| Researcher | 12 | 14% |
| Student > Doctoral Student | 7 | 8% |
| Other | 6 | 7% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 30% |
| Biochemistry, Genetics and Molecular Biology | 13 | 15% |
| Neuroscience | 13 | 15% |
| Medicine and Dentistry | 6 | 7% |
| Psychology | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 17 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2014.
All research outputs
#2,693,579
of 22,760,687 outputs
Outputs from Neuroscience Bulletin
#50
of 762 outputs
Outputs of similar age
#28,347
of 229,519 outputs
Outputs of similar age from Neuroscience Bulletin
#1
of 8 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 762 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them