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The Par-PrkC Polarity Complex Is Required for Cilia Growth in Zebrafish Photoreceptors

Overview of attention for article published in PLOS ONE, August 2014
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Title
The Par-PrkC Polarity Complex Is Required for Cilia Growth in Zebrafish Photoreceptors
Published in
PLOS ONE, August 2014
DOI 10.1371/journal.pone.0104661
Pubmed ID
Authors

Bryan L. Krock, Brian D. Perkins

Abstract

Specification and development of the apical membrane in epithelial cells requires the function of polarity proteins, including Pard3 and an atypical protein kinase C (PrkC). Many epithelial cells possess microtubule-based organelles, known as cilia, that project from their apical surface and the membrane surrounding the cilium is contiguous with the apical cell membrane. Although cilia formation in cultured cells required Pard3, the in vivo requirement for Pard3 in cilia development remains unknown. The vertebrate photoreceptor outer segment represents a highly specialized cilia structure in which to identify factors necessary for apical and ciliary membrane formation. Pard3 and PrkC localized to distinct domains within vertebrate photoreceptors. Using partial morpholino knockdown, photo-morpholinos, and pharmacological approaches, the function of Pard3 and PrkC were found to be required for the formation of both the apical and ciliary membrane of vertebrate photoreceptors. Inhibition of Pard3 or PrkC activity significantly reduced the size of photoreceptor outer segments and resulted in mislocalization of rhodopsin. Suppression of Pard3 or PrkC also led to a reduction in cilia size and cilia number in Kupffer's Vesicle, which resulted in left-right asymmetry defects. Thus, the Par-PrkC complex functions in cilia formation in vivo and this likely reflects a general role in specifying non-ciliary and ciliary compartments of the apical domain.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Ph. D. Student 7 18%
Student > Master 5 13%
Student > Bachelor 3 8%
Student > Doctoral Student 2 5%
Other 7 18%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 34%
Biochemistry, Genetics and Molecular Biology 13 34%
Neuroscience 4 11%
Medicine and Dentistry 3 8%
Veterinary Science and Veterinary Medicine 1 3%
Other 0 0%
Unknown 4 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2014.
All research outputs
#14,198,795
of 22,760,687 outputs
Outputs from PLOS ONE
#116,145
of 194,199 outputs
Outputs of similar age
#121,487
of 235,897 outputs
Outputs of similar age from PLOS ONE
#2,541
of 4,887 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,199 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,897 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,887 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.