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Mendeley readers
Attention Score in Context
| Title |
Requirement for CDK4 kinase function in breast cancer
|
|---|---|
| Published in |
Cancer Cell, January 2006
|
| DOI | 10.1016/j.ccr.2005.12.012 |
| Pubmed ID | |
| Authors |
Qunyan Yu, Ewa Sicinska, Yan Geng, Marie Ahnström, Agnieszka Zagozdzon, Yinxin Kong, Humphrey Gardner, Hiroaki Kiyokawa, Lyndsay N. Harris, Olle Stål, Piotr Sicinski |
| Abstract |
Cyclin D1 is overexpressed in the majority of human breast cancers. We previously found that mice lacking cyclin D1 are resistant to mammary carcinomas triggered by the ErbB-2 oncogene. In this study, we investigated which function of cyclin D1 is required for ErbB-2-driven mammary oncogenesis. We report that the ability of cyclin D1 to activate cyclin-dependent kinase CDK4 underlies the critical role for cyclin D1 in breast cancer formation. We also found that the continued presence of CDK4-associated kinase activity is required to maintain breast tumorigenesis. We analyzed primary human breast cancers and found high cyclin D1 levels in a subset (approximately 25%) of ErbB-2-overexpressing tumors. We propose that this subset of breast cancer patients might benefit from inhibiting CDK4 kinase. |
Mendeley readers
The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| China | 2 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 191 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 18% |
| Student > Master | 29 | 14% |
| Researcher | 25 | 12% |
| Student > Bachelor | 20 | 10% |
| Student > Doctoral Student | 8 | 4% |
| Other | 32 | 16% |
| Unknown | 52 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 46 | 23% |
| Medicine and Dentistry | 39 | 19% |
| Biochemistry, Genetics and Molecular Biology | 38 | 19% |
| Chemistry | 7 | 3% |
| Neuroscience | 4 | 2% |
| Other | 10 | 5% |
| Unknown | 58 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2023.
All research outputs
#1,617,063
of 25,374,917 outputs
Outputs from Cancer Cell
#1,112
of 3,149 outputs
Outputs of similar age
#4,125
of 174,008 outputs
Outputs of similar age from Cancer Cell
#1
of 15 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,008 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.