| Title |
Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, May 2010
|
| DOI | 10.1007/s00228-010-0831-4 |
| Pubmed ID | |
| Authors |
Andrea Gaedigk, Maria Isidoro-García, Robin E. Pearce, Santiago Sánchez, Virginia García-Solaesa, Carolina Lorenzo-Romo, Gloria Gonzalez-Tejera, Susan Corey |
| Abstract |
CYP2D6 31 (4042G>A, R(440)H) is an allelic variant of the highly polymorphic cytochrome P450 2D6 enzyme that has been associated with reduced functional activity. The US Food and Drug Administration (FDA)-cleared AmpliChip CYP450 test detects the 4042G>A single nucleotide polymorphism (SNP) but an allele assignment could not be made in two Spanish and two Puerto Rican individuals heterozygous for 4042G>A, resulting in no-calls. We aimed to resolve the CYP2D6 31 no-calls, determine the allele haplotype, and corroborate that CYP2D6 31 is associated with a poor metabolizer phenotype. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Thailand | 1 | 3% |
| South Africa | 1 | 3% |
| Unknown | 27 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 21% |
| Researcher | 6 | 21% |
| Student > Bachelor | 4 | 14% |
| Student > Master | 4 | 14% |
| Student > Doctoral Student | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 28% |
| Agricultural and Biological Sciences | 8 | 28% |
| Medicine and Dentistry | 4 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Physics and Astronomy | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 5 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2014.
All research outputs
#15,304,580
of 22,761,738 outputs
Outputs from European Journal of Clinical Pharmacology
#2,044
of 2,557 outputs
Outputs of similar age
#77,240
of 95,107 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#12
of 13 outputs
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