| Title |
Diabetes Mellitus and Disturbances in Brain Connectivity: A Bidirectional Relationship?
|
|---|---|
| Published in |
NeuroMolecular Medicine, June 2014
|
| DOI | 10.1007/s12017-014-8316-8 |
| Pubmed ID | |
| Authors |
Rodrigo B. Mansur, Danielle S. Cha, Hanna O. Woldeyohannes, Joanna K. Soczynska, Andre Zugman, Elisa Brietzke, Roger S. McIntyre |
| Abstract |
Diabetes mellitus (DM) is associated with deficits across multiple cognitive domains. The observed impairments in cognitive function are hypothesized to be subserved by alterations in brain structure and function. Several lines of evidence indicate that alterations in glial integrity and function, as well as abnormal synchrony within brain circuits and associated networks, are observed in adults with DM. Microangiopathy and alterations in insulin homeostasis appear to be principal effector systems, although a unitary explanation subsuming the complex etiopathology of white matter in DM is unavailable. A contemporary model of disease pathophysiology for several mental disorders, including but not limited to mood disorders, posits abnormalities in the synchronization of cellular systems in circuits. The observation that similar abnormalities occur in diabetic populations provides the basis for hypothesizing the convergence of pathoetiological factors. Herein, we propose that abnormal structure, function and chemical composition as well as synchrony within and between circuits is an accompaniment of DM and is shared in common with several mental disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 22% |
| Student > Master | 10 | 15% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Bachelor | 7 | 10% |
| Student > Doctoral Student | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 27% |
| Neuroscience | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Psychology | 5 | 7% |
| Agricultural and Biological Sciences | 4 | 6% |
| Other | 10 | 15% |
| Unknown | 15 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2014.
All research outputs
#3,267,939
of 22,761,738 outputs
Outputs from NeuroMolecular Medicine
#87
of 447 outputs
Outputs of similar age
#33,755
of 227,017 outputs
Outputs of similar age from NeuroMolecular Medicine
#1
of 11 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 447 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,017 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.