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CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma

Overview of attention for article published in Oncotarget, July 2014
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Title
CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma
Published in
Oncotarget, July 2014
DOI 10.18632/oncotarget.2269
Pubmed ID
Authors

Oihana Murillo-Sauca, Man Ki Chung, June Ho Shin, Christina Karamboulas, Shirley Kwok, Young Ho Jung, Richard Oakley, James R. Tysome, Lovisa O. Farnebo, Michael J. Kaplan, Davud Sirjani, Vasu Divi, F. Christopher Holsinger, Chafeek Tomeh, Anthony Nichols, Quynh T. Le, A. A. Dimitrios Colevas, Christina S. Kong, Ravindra Uppaluri, James S. Lewis, Laurie E. Ailles, John B. Sunwoo

Abstract

Tumor-initiating cells (TICs) in squamous cell carcinoma of the head and neck (SCCHN) are best characterized by their surface expression of CD44. Although there is great interest in identifying strategies to target this population, no marker of these cells has been found to be functionally active. Here, we examined the expression of the purported marker of normal human oral epithelial stem cells, CD271. We show that CD271 expression is restricted to a subset of the CD44+ cells. Using xenograft assays, we show that the CD44+CD271+ subpopulation contains the most tumorigenic cells. Loss of CD271 function results in a block in the G2-M phase of the cell cycle and a profound negative impact on the capacity of these cells to initiate tumor formation in vivo. Incubation with recombinant NGF results in enhanced phosphorylation of Erk, providing additional evidence that CD271 is functionally active. Finally, incubation of SCCHN cells with antibody to CD271 results in decreased Erk phosphorylation and decreased tumor formation in vivo. Thus, our data are the first to demonstrate that CD271 more specifically identifies the TIC subpopulation within the CD44+ compartment in SCCHN and that this receptor is a functionally active and targetable molecule.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Denmark 1 2%
Luxembourg 1 2%
Unknown 52 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 29%
Researcher 10 18%
Student > Master 5 9%
Professor > Associate Professor 4 7%
Student > Doctoral Student 3 5%
Other 8 15%
Unknown 9 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 29%
Medicine and Dentistry 9 16%
Agricultural and Biological Sciences 5 9%
Immunology and Microbiology 5 9%
Chemistry 2 4%
Other 6 11%
Unknown 12 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2015.
All research outputs
#19,015,492
of 23,577,654 outputs
Outputs from Oncotarget
#8,634
of 14,436 outputs
Outputs of similar age
#165,992
of 231,205 outputs
Outputs of similar age from Oncotarget
#122
of 186 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,436 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,205 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.