Title |
Connecting the dots between tau dysfunction and neurodegeneration
|
---|---|
Published in |
Trends in Cell Biology, August 2014
|
DOI | 10.1016/j.tcb.2014.07.005 |
Pubmed ID | |
Authors |
Bess Frost, Jürgen Götz, Mel B. Feany |
Abstract |
Tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. Identifying the causes of abnormal tau phosphorylation and subsequent aggregation has been the focus of much research, and is currently a major target for the development of therapeutic interventions for tauopathies, including Alzheimer's disease (AD). Much has recently been learned about the sequence of events that lead from tau dysfunction to neuronal death. This review focuses on the cascade of events that are catalyzed by pathological tau, and highlights current and potential therapeutic strategies to target this pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
Australia | 1 | 13% |
Netherlands | 1 | 13% |
United Kingdom | 1 | 13% |
Canada | 1 | 13% |
France | 1 | 13% |
Unknown | 1 | 13% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Science communicators (journalists, bloggers, editors) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 1% |
United States | 2 | <1% |
Korea, Republic of | 2 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Chile | 1 | <1% |
Unknown | 232 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 64 | 26% |
Researcher | 44 | 18% |
Student > Bachelor | 30 | 12% |
Student > Master | 27 | 11% |
Student > Doctoral Student | 14 | 6% |
Other | 34 | 14% |
Unknown | 29 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 71 | 29% |
Neuroscience | 49 | 20% |
Biochemistry, Genetics and Molecular Biology | 41 | 17% |
Medicine and Dentistry | 20 | 8% |
Chemistry | 8 | 3% |
Other | 18 | 7% |
Unknown | 35 | 14% |