| Title |
Structural and functional roles of ether lipids
|
|---|---|
| Published in |
Protein & Cell, May 2017
|
| DOI | 10.1007/s13238-017-0423-5 |
| Pubmed ID | |
| Authors |
John M Dean, Irfan J Lodhi |
| Abstract |
Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seemingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential significance in human disorders, including neurological diseases, cancer, and metabolic disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 418 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 418 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 19% |
| Researcher | 58 | 14% |
| Student > Master | 55 | 13% |
| Student > Bachelor | 51 | 12% |
| Student > Doctoral Student | 26 | 6% |
| Other | 39 | 9% |
| Unknown | 111 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 131 | 31% |
| Agricultural and Biological Sciences | 46 | 11% |
| Chemistry | 29 | 7% |
| Medicine and Dentistry | 20 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 3% |
| Other | 51 | 12% |
| Unknown | 129 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2022.
All research outputs
#5,559,757
of 25,837,817 outputs
Outputs from Protein & Cell
#237
of 827 outputs
Outputs of similar age
#88,602
of 329,430 outputs
Outputs of similar age from Protein & Cell
#13
of 25 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 827 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,430 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.