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Mendeley readers
Attention Score in Context
| Title |
Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, September 2017
|
| DOI | 10.1016/j.bmcl.2017.09.027 |
| Pubmed ID | |
| Authors |
Bo-wei Zhang, Yan Xing, Chen Wen, Xiao-xia Yu, Wen-long Sun, Zhi-long Xiu, Yue-sheng Dong |
| Abstract |
In this paper, the inhibition of α-amylase and α-glucosidase by nine pentacyclic triterpenes was determined. For α-amylase inhibitory activity, the IC50 values of ursolic acid, corosolic acid, and oleanolic acid were 22.6±2.4μM, 31.2±3.4μM, and 94.1±6.7μM, respectively. For α-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1±1.0μM, 17.2±0.9μM, 14.9±1.9μM, and 35.6±2.6μM, respectively. The combination of corosolic acid and oleanolic acid with acarbose showed synergistic inhibition against α-amylase. The combination of the tested triterpenes with acarbose mainly exhibited additive inhibition against α-glucosidase. Kinetic studies revealed that corosolic acid and oleanolic acid showed non-competitive inhibition and acarbose showed mixed-type inhibition against α-amylase. The results provide valuable implications for the triterpenes (ursolic acid, corosolic acid, and oleanolic acid) alone or in combination with acarbose as a therapeutic agent for the treatment of diabetes mellitus. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 107 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 20% |
| Student > Ph. D. Student | 18 | 17% |
| Student > Master | 10 | 9% |
| Researcher | 9 | 8% |
| Student > Doctoral Student | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 29 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 17% |
| Chemistry | 13 | 12% |
| Agricultural and Biological Sciences | 12 | 11% |
| Medicine and Dentistry | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 40 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2017.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#12,194
of 13,780 outputs
Outputs of similar age
#207,621
of 323,438 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#62
of 98 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,780 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,438 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.