| Title |
Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial
|
|---|---|
| Published in |
Supportive Care in Cancer, September 2017
|
| DOI | 10.1007/s00520-017-3881-7 |
| Pubmed ID | |
| Authors |
Gary Deng, Sergio Giralt, David J. Chung, Heather Landau, Jonathan Siman, Benjamin Search, Marci Coleton, Emily Vertosick, Nathan Shapiro, Christine Chien, Xin S. Wang, Barrie Cassileth, Jun J. Mao |
| Abstract |
Hematopoietic stem cell transplantation (HCT) is potentially curative for a number of hematologic malignancies, but is associated with high symptom burden. We conducted a randomized sham-controlled trial (RCT) to evaluate efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during HCT. Adult patients with multiple myeloma undergoing high-dose melphalan followed by autologous HCT (AHCT) were randomized to receive either true or sham acupuncture once daily for 5 days starting the day after chemotherapy. Patients and clinical evaluators, but not acupuncturists, were blinded to group assignment. Symptom burden, the primary outcome was assessed with the MD Anderson Symptom Inventory (MDASI) at baseline, during transplantation, and at 15 and 30 days post transplantation. Among 60 participants, true acupuncture produced nonsignificant reductions in overall MDASI core symptom scores and symptom interference scores during transplantation (P = .4 and .3, respectively), at 15 days (P = .10 and .3), and at 30 days posttransplantation (P = .2 and .4) relative to sham. However, true acupuncture was significantly more efficacious in reducing nausea, lack of appetite, and drowsiness at 15 days (P = .042, .025, and .010, respectively). Patients receiving sham acupuncture were more likely to increase pain medication use posttransplantation (odds ratio 5.31, P = .017). Acupuncture was well tolerated with few attributable adverse events. True acupuncture may prevent escalation of symptoms including nausea, lack of appetite, and drowsiness experienced by patients undergoing AHCT, and reduce the use of pain medications. These findings need to be confirmed in a future definitive study. NCT01811862. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 27% |
| Spain | 4 | 12% |
| Canada | 4 | 12% |
| Brazil | 2 | 6% |
| Germany | 1 | 3% |
| United Kingdom | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Australia | 1 | 3% |
| Unknown | 10 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 64% |
| Practitioners (doctors, other healthcare professionals) | 6 | 18% |
| Scientists | 4 | 12% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 9 | 10% |
| Researcher | 7 | 8% |
| Student > Bachelor | 7 | 8% |
| Student > Master | 6 | 7% |
| Student > Ph. D. Student | 4 | 4% |
| Other | 12 | 13% |
| Unknown | 46 | 51% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 30% |
| Nursing and Health Professions | 10 | 11% |
| Unspecified | 3 | 3% |
| Engineering | 2 | 2% |
| Sports and Recreations | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 46 | 51% |
Attention Score in Context
This research output has an Altmetric Attention Score of 54. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2019.
All research outputs
#740,191
of 24,321,976 outputs
Outputs from Supportive Care in Cancer
#49
of 4,870 outputs
Outputs of similar age
#15,916
of 321,553 outputs
Outputs of similar age from Supportive Care in Cancer
#2
of 73 outputs
Altmetric has tracked 24,321,976 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,870 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.