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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype
|
|---|---|
| Published in |
International Journal of Cancer, October 2017
|
| DOI | 10.1002/ijc.31049 |
| Pubmed ID | |
| Authors |
Harindra Jayasekara, Dallas R. English, Andrew Haydon, Allison M. Hodge, Brigid M. Lynch, Christophe Rosty, Elizabeth J. Williamson, Mark Clendenning, Melissa C. Southey, Mark A. Jenkins, Robin Room, John L. Hopper, Roger L. Milne, Daniel D. Buchanan, Graham G. Giles, Robert J. MacInnis |
| Abstract |
The influence of lifestyle factors on survival following a diagnosis of colorectal cancer (CRC) is not well established. We examined associations between lifestyle factors measured before diagnosis and CRC survival. The Melbourne Collaborative Cohort Study collected data on alcohol intake, cigarette smoking and physical activity, and body measurements at baseline (1990-94) and wave 2 (2003-07). We included participants diagnosed to 31 August 2015 with incident stage I-III CRC within 10-years post exposure assessment. Information on tumor characteristics and vital status was obtained. Tumor DNA was tested for microsatellite instability (MSI) and somatic mutations in oncogenes BRAF (V600E) and KRAS. We estimated hazard ratios (HRs) for associations between lifestyle factors and overall and CRC-specific mortality using Cox regression. Of 724 eligible CRC cases, 339 died (170 from CRC) during follow-up (average 9.0 years). Exercise (non-occupational/leisure-time) was associated with higher CRC-specific survival for stage II (HR = 0.25, 95% CI: 0.10-0.60) but not stage I/III disease (p for interaction = .01), and possibly for colon and KRAS wild-type tumors. Waist circumference was inversely associated with CRC-specific survival (HR = 1.25 per 10 cm increment, 95% CI: 1.08-1.44), independent of stage, anatomic site and tumor molecular status. Cigarette smoking was associated with lower overall survival, with suggestive evidence of worse survival for BRAF mutated CRC, but not with CRC-specific survival. Alcohol intake was not associated with survival. Survival did not differ by MSI status. We have identified pre-diagnostic predictors of survival following CRC that may have clinical and public health relevance. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 140 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 11% |
| Student > Bachelor | 16 | 11% |
| Student > Master | 13 | 9% |
| Student > Ph. D. Student | 12 | 9% |
| Student > Postgraduate | 7 | 5% |
| Other | 15 | 11% |
| Unknown | 61 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 22% |
| Nursing and Health Professions | 11 | 8% |
| Sports and Recreations | 7 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 15 | 11% |
| Unknown | 66 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2017.
All research outputs
#3,455,287
of 24,525,936 outputs
Outputs from International Journal of Cancer
#1,499
of 12,085 outputs
Outputs of similar age
#62,377
of 327,433 outputs
Outputs of similar age from International Journal of Cancer
#28
of 115 outputs
Altmetric has tracked 24,525,936 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,085 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.