| Title |
Parasiticidal activity of human α-defensin-5 against Toxoplasma gondii
|
|---|---|
| Published in |
In Vitro Cellular & Developmental Biology - Animal, February 2010
|
| DOI | 10.1007/s11626-009-9271-9 |
| Pubmed ID | |
| Authors |
Tetsuya Tanaka, Md. Morshedur Rahman, Banzragch Battur, Damdinsuren Boldbaatar, Min Liao, Rika Umemiya-Shirafuji, Xuenan Xuan, Kozo Fujisaki |
| Abstract |
Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. In this paper, we show that human alpha-defensin-5 displays a parasiticidal role against Toxoplasma gondii, the causative agent of toxoplasmosis. Exposure of the tachyzoite form of T. gondii to defensin induced aggregation and significantly reduced parasite viability in a concentration-dependent peptide. Pre-incubation of tachyzoites with human alpha-defensin-5 followed by exposure to a mouse embryonal cell line (NIH/3T3) significantly reduced T. gondii infection in these cells. Thus, human alpha-defensin-5 is an innate immune molecule that causes severe toxocity to T. gondii and plays an important role in reducing cellular infection. This is the first report showing that human alpha-defensin-5 causes aggregation, leading to Toxoplasma destruction. |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 14% |
| Student > Master | 6 | 14% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 3 | 7% |
| Professor | 3 | 7% |
| Other | 11 | 25% |
| Unknown | 10 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 27% |
| Immunology and Microbiology | 5 | 11% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Veterinary Science and Veterinary Medicine | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2018.
All research outputs
#7,445,571
of 22,761,738 outputs
Outputs from In Vitro Cellular & Developmental Biology - Animal
#155
of 789 outputs
Outputs of similar age
#48,862
of 165,279 outputs
Outputs of similar age from In Vitro Cellular & Developmental Biology - Animal
#3
of 7 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 789 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,279 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.