| Title |
Oxidative DNA Damage in Barrett Mucosa: Correlation with Telomeric Dysfunction and p53 Mutation
|
|---|---|
| Published in |
Annals of Surgical Oncology, June 2013
|
| DOI | 10.1245/s10434-013-3043-1 |
| Pubmed ID | |
| Authors |
Romilda Cardin, Marika Piciocchi, Chiara Tieppo, Gemma Maddalo, Giovanni Zaninotto, Claudia Mescoli, Massimo Rugge, Fabio Farinati |
| Abstract |
Barrett esophagus develops in a scenario of chronic inflammation, linked to free radical formation and oxidative DNA damage. Eight-hydroxydeoxyguanosine, the main oxidative DNA adduct, is partially repaired by a glycosylase (OGG1) whose polymorphism is associated to a reduced repair capacity. Telomeres are particularly prone to oxidative damage, which leads to shortening and cell senescence, while elongation, by telomerase activity, is linked to cell immortalization and cancer. Limited data are available on this point with respect to Barrett esophagus. This study aimed to evaluate the link among 8-hydroxydeoxyguanosine, OGG1 polymorphism, telomerase activity, telomere length, and p53 mutation in Barrett progression. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 24% |
| Student > Ph. D. Student | 2 | 12% |
| Professor | 2 | 12% |
| Student > Bachelor | 1 | 6% |
| Lecturer | 1 | 6% |
| Other | 5 | 29% |
| Unknown | 2 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 35% |
| Biochemistry, Genetics and Molecular Biology | 4 | 24% |
| Agricultural and Biological Sciences | 4 | 24% |
| Computer Science | 1 | 6% |
| Unknown | 2 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2014.
All research outputs
#20,235,415
of 22,761,738 outputs
Outputs from Annals of Surgical Oncology
#5,483
of 6,446 outputs
Outputs of similar age
#172,575
of 197,556 outputs
Outputs of similar age from Annals of Surgical Oncology
#45
of 48 outputs
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