| Title |
Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects
|
|---|---|
| Published in |
Journal of Inherited Metabolic Disease, September 2010
|
| DOI | 10.1007/s10545-010-9177-4 |
| Pubmed ID | |
| Authors |
Henk J. Blom, Yvo Smulders |
| Abstract |
This overview addresses homocysteine and folate metabolism. Its functions and complexity are described, leading to explanations why disturbed homocysteine and folate metabolism is implicated in many different diseases, including congenital birth defects like congenital heart disease, cleft lip and palate, late pregnancy complications, different kinds of neurodegenerative and psychiatric diseases, osteoporosis and cancer. In addition, the inborn errors leading to hyperhomocysteinemia and homocystinuria are described. These extreme human hyperhomocysteinemia models provide knowledge about which part of the homocysteine and folate pathways are linked to which disease. For example, the very high risk for arterial and venous occlusive disease in patients with severe hyperhomocysteinemia irrespective of the location of the defect in remethylation or transsulphuration indicates that homocysteine itself or one of its "direct" derivatives is considered toxic for the cardiovascular system. Finally, common diseases associated with elevated homocysteine are discussed with the focus on cardiovascular disease and neural tube defects. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 18% |
| Unknown | 9 | 82% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 45% |
| Practitioners (doctors, other healthcare professionals) | 3 | 27% |
| Scientists | 1 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
| Unknown | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 555 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Canada | 2 | <1% |
| United States | 2 | <1% |
| Finland | 1 | <1% |
| Russia | 1 | <1% |
| Colombia | 1 | <1% |
| Unknown | 545 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 117 | 21% |
| Student > Master | 85 | 15% |
| Student > Ph. D. Student | 82 | 15% |
| Researcher | 61 | 11% |
| Student > Doctoral Student | 31 | 6% |
| Other | 100 | 18% |
| Unknown | 79 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 130 | 23% |
| Agricultural and Biological Sciences | 109 | 20% |
| Biochemistry, Genetics and Molecular Biology | 107 | 19% |
| Nursing and Health Professions | 35 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 3% |
| Other | 54 | 10% |
| Unknown | 104 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2021.
All research outputs
#2,883,938
of 25,670,640 outputs
Outputs from Journal of Inherited Metabolic Disease
#119
of 2,014 outputs
Outputs of similar age
#11,007
of 105,311 outputs
Outputs of similar age from Journal of Inherited Metabolic Disease
#2
of 15 outputs
Altmetric has tracked 25,670,640 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,014 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,311 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.