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High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain

Overview of attention for article published in Pain (03043959), September 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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Title
High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain
Published in
Pain (03043959), September 2017
DOI 10.1097/j.pain.0000000000001061
Pubmed ID
Authors

Emmanuel Bäckryd, Anne-Li Lind, Måns Thulin, Anders Larsson, Björn Gerdle, Torsten Gordh

Abstract

Animal models suggest that chemokines are important mediators in the pathophysiology of neuropathic pain. Indeed, these substances have been called "gliotransmitters", a term that illustrates the close interplay between glial cells and neurons in the context of neuroinflammation and pain. However, evidence in humans is scarce. The aim of the study was to determine a comprehensive cerebrospinal fluid (CSF) inflammatory profile for neuropathic pain patients. Our hypothesis was that we would thereby find indications of a postulated on-going process of central neuroinflammation.CSF samples were collected from two cohorts of patients with neuropathic pain (n=11 and n=16, respectively) and healthy controls (n=11). The samples were analyzed with a multiplex proximity extension assay in which 92 inflammation-related proteins were measured simultaneously (Proseek® Multiplex Inflammation I, Olink Bioscience, Uppsala, Sweden). Univariate testing with control of false discovery rate, as well as orthogonal partial least squares - discriminant analysis, were used for statistical analyses.CSF levels of chemokines CXCL6, CXCL10, CCL8, CCL11, CCL23, as well as protein LAPTGF-beta-1, were significantly higher in both neuropathic pain cohorts compared to healthy controls, pointing to neuroinflammation in patients. These 6 proteins were also major results in a recent similar study in fibromyalgia patients. The findings need to be confirmed in larger cohorts, and the question of causality remains to be settled. Since it has been suggested that prevalent co-morbidities to chronic pain (e.g., depression, anxiety, poor sleep, and tiredness) also are associated with neuroinflammation, it will be important to determine whether neuroinflammation is a common mediator.This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

X Demographics

X Demographics

The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 110 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 21%
Student > Bachelor 13 12%
Student > Master 11 10%
Researcher 7 6%
Student > Doctoral Student 5 5%
Other 17 15%
Unknown 34 31%
Readers by discipline Count As %
Medicine and Dentistry 22 20%
Neuroscience 14 13%
Nursing and Health Professions 9 8%
Psychology 6 5%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 16 15%
Unknown 38 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2022.
All research outputs
#1,765,656
of 25,382,440 outputs
Outputs from Pain (03043959)
#904
of 6,470 outputs
Outputs of similar age
#33,840
of 325,430 outputs
Outputs of similar age from Pain (03043959)
#16
of 48 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,470 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,430 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.