| Title |
Zebrafish as a model to study the role of DNA methylation in environmental toxicology
|
|---|---|
| Published in |
Environmental Science and Pollution Research, August 2014
|
| DOI | 10.1007/s11356-014-3466-7 |
| Pubmed ID | |
| Authors |
Jorke H. Kamstra, Peter Aleström, Jan M. Kooter, Juliette Legler |
| Abstract |
Environmental epigenetics is a rapidly growing field which studies the effects of environmental factors such as nutrition, stress, and exposure to compounds on epigenetic gene regulation. Recent studies have shown that exposure to toxicants in vertebrates is associated with changes in DNA methylation, a major epigenetic mechanism affecting gene transcription. Zebra fish, a well-known model in toxicology and developmental biology, are emerging as a model species in environmental epigenetics despite their evolutionary distance to rodents and humans. In this review, recent insights in DNA methylation during zebra fish development are discussed and compared to mammalian models in order to evaluate zebra fish as a model to study the role of DNA methylation in environmental toxicology. Differences exist in DNA methylation reprogramming during early development, whereas in later developmental stages, tissue distribution of both 5-methylcytosine and 5-hydroxymethylcytosine seems more conserved between species, as well as basic DNA (de)methylation mechanisms. All DNA methyl transferases identified so far in mammals are present in zebra fish, as well as a number of major demethylation pathways. However, zebra fish appear to lack some methylation pathways present in mammals, such as parental imprinting. Several studies report effects on DNA methylation in zebra fish following exposure to environmental contaminants, such as arsenic, benzo[a]pyrene, and tris(1,3-dichloro-2-propyl)phosphate. Though more research is needed to examine heritable effects of contaminant exposure on DNA methylation, recent data suggests the usefulness of the zebra fish as a model in environmental epigenetics. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 220 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | <1% |
| United Kingdom | 2 | <1% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 211 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 19% |
| Student > Master | 41 | 19% |
| Student > Bachelor | 26 | 12% |
| Researcher | 24 | 11% |
| Student > Doctoral Student | 14 | 6% |
| Other | 34 | 15% |
| Unknown | 40 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 39% |
| Biochemistry, Genetics and Molecular Biology | 34 | 15% |
| Environmental Science | 20 | 9% |
| Chemistry | 7 | 3% |
| Medicine and Dentistry | 6 | 3% |
| Other | 21 | 10% |
| Unknown | 47 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2014.
All research outputs
#16,174,923
of 23,911,072 outputs
Outputs from Environmental Science and Pollution Research
#3,697
of 9,883 outputs
Outputs of similar age
#139,843
of 240,240 outputs
Outputs of similar age from Environmental Science and Pollution Research
#53
of 125 outputs
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So far Altmetric has tracked 9,883 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
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We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.