Title |
Ipilimumab and Its Toxicities: A Multidisciplinary Approach
|
---|---|
Published in |
Oncologist, June 2013
|
DOI | 10.1634/theoncologist.2012-0483 |
Pubmed ID | |
Authors |
Leslie A. Fecher, Sanjiv S. Agarwala, F. Stephen Hodi, Jeffrey S. Weber |
Abstract |
The treatment for metastatic melanoma has evolved significantly in the past few years. Ipilimumab, an immunotherapy, is now in mainstream oncology practice given that it has shown improved overall survival in randomized clinical trials. Other immune modulating agents, such as programmed death receptor-1 and programmed death receptor ligand-1 antibodies, are showing promise in early clinical trials. This manuscript will review ipilimumab and its most common side effects. Immune-related adverse events (irAEs) are important to recognize early, and their presentation, timing of onset, and general recommendations for workup and management will be reviewed. Assembling a multidisciplinary team, as well as thorough education of the patient, is recommended to optimize patient care. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
France | 1 | <1% |
Unknown | 186 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 15% |
Researcher | 26 | 14% |
Student > Master | 25 | 13% |
Student > Ph. D. Student | 22 | 12% |
Other | 19 | 10% |
Other | 28 | 15% |
Unknown | 43 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 70 | 37% |
Agricultural and Biological Sciences | 19 | 10% |
Biochemistry, Genetics and Molecular Biology | 16 | 8% |
Nursing and Health Professions | 10 | 5% |
Immunology and Microbiology | 10 | 5% |
Other | 20 | 10% |
Unknown | 46 | 24% |