| Title |
Aging, Osteocytes, and Mechanotransduction
|
|---|---|
| Published in |
Current Osteoporosis Reports, September 2017
|
| DOI | 10.1007/s11914-017-0402-z |
| Pubmed ID | |
| Authors |
Haniyeh Hemmatian, Astrid D. Bakker, Jenneke Klein-Nulend, G. Harry van Lenthe |
| Abstract |
The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging. Several studies have reported considerable variations in the shape of osteocytes and their lacunae with aging. Since osteocytes can sense matrix strain directly via their cell bodies, the variations in osteocyte morphology may cause changes in osteocyte mechanosensitivity. As a consequence, the load-adaptive response of osteocytes may change with aging, even when mechanical loading would remain unchanged. Though extensive quantitative data is lacking, evidence exists that the osteocyte lacunae are becoming smaller and more spherical with aging. Future dedicated studies might reveal whether these changes would affect osteocyte mechanosensation and the subsequent biological response, and whether this is (one of) the pathways involved in age-related bone loss. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 194 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 25% |
| Researcher | 28 | 14% |
| Student > Master | 22 | 11% |
| Student > Bachelor | 19 | 10% |
| Professor > Associate Professor | 8 | 4% |
| Other | 19 | 10% |
| Unknown | 49 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 38 | 20% |
| Medicine and Dentistry | 30 | 15% |
| Biochemistry, Genetics and Molecular Biology | 25 | 13% |
| Agricultural and Biological Sciences | 11 | 6% |
| Nursing and Health Professions | 6 | 3% |
| Other | 23 | 12% |
| Unknown | 61 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2017.
All research outputs
#20,447,499
of 23,002,898 outputs
Outputs from Current Osteoporosis Reports
#473
of 549 outputs
Outputs of similar age
#276,091
of 316,068 outputs
Outputs of similar age from Current Osteoporosis Reports
#16
of 16 outputs
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