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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic variability in the regulation of gene expression in ten regions of the human brain
|
|---|---|
| Published in |
Nature Neuroscience, August 2014
|
| DOI | 10.1038/nn.3801 |
| Pubmed ID | |
| Authors |
Adaikalavan Ramasamy, Daniah Trabzuni, Sebastian Guelfi, Vibin Varghese, Colin Smith, Robert Walker, Tisham De, Lachlan Coin, Rohan de Silva, Mark R Cookson, Andrew B Singleton, John Hardy, Mina Ryten, Michael E Weale |
| Abstract |
Germ-line genetic control of gene expression occurs via expression quantitative trait loci (eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions. We found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression analysis of the same samples. We report cis-eQTL signals for 23.1% of catalogued genome-wide association study hits for adult-onset neurological disorders. The data set is publicly available via public data repositories and via http://www.braineac.org/. Our study increases our understanding of the regulation of gene expression in the human brain and will be of value to others pursuing functional follow-up of disease-associated variants. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 31% |
| United Kingdom | 2 | 8% |
| Netherlands | 2 | 8% |
| Canada | 1 | 4% |
| Germany | 1 | 4% |
| Ireland | 1 | 4% |
| Unknown | 11 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 58% |
| Scientists | 10 | 38% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 499 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 2% |
| United Kingdom | 5 | 1% |
| Italy | 2 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Hungary | 1 | <1% |
| Brazil | 1 | <1% |
| Colombia | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 470 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 128 | 26% |
| Researcher | 110 | 22% |
| Student > Bachelor | 33 | 7% |
| Student > Master | 31 | 6% |
| Professor | 30 | 6% |
| Other | 98 | 20% |
| Unknown | 69 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 145 | 29% |
| Biochemistry, Genetics and Molecular Biology | 93 | 19% |
| Neuroscience | 55 | 11% |
| Medicine and Dentistry | 42 | 8% |
| Computer Science | 17 | 3% |
| Other | 49 | 10% |
| Unknown | 98 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2023.
All research outputs
#886,542
of 25,837,817 outputs
Outputs from Nature Neuroscience
#1,504
of 5,675 outputs
Outputs of similar age
#8,662
of 250,488 outputs
Outputs of similar age from Nature Neuroscience
#22
of 69 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,675 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,488 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.