Title |
Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: A meta-analysis, 1985–2010
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Published in |
Oral Oncology, August 2011
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DOI | 10.1016/j.oraloncology.2011.07.009 |
Pubmed ID | |
Authors |
Vijayvel Jayaprakash, Mary Reid, Elizabeth Hatton, Mihai Merzianu, Nestor Rigual, James Marshall, Steve Gill, Jennifer Frustino, Gregory Wilding, Thom Loree, Saurin Popat, Maureen Sullivan |
Abstract |
Human papillomavirus (HPV) types 16 and 18 are causally related to a sub-set of oral cavity and oropharyngeal squamous cell cancers. However, a clear estimate of the prevalence of HPV-16/18 in oral cavity and oropharyngeal dysplasia (OOPD) is not available. This literature review and meta-analysis was conducted to provide a prevalence estimate for HPV-16/18 in OOPD. Twenty-two studies that reported prevalence of HPV-16 and/or 18 in 458 OOPD lesions were analyzed. Meta-analysis was used to evaluate the prevalence of HPV-16/18 and logistic regression was used for stratified analysis by age, gender, and histological grade. The overall prevalence of HPV-16/18 in OOPD lesions was 24.5% [95% confidence interval (CI), 16.4-36.7%)]. The individual prevalence for HPV-16 alone was 24.4%. The prevalence of HPV-16/18 in oral cavity lesions alone was 25.3% (95% CI, 14.2-45.2%). The odds of detection of HPV-16/18 in dysplastic lesions in males were twice that of females [odds ratio (OR), 2.44]. HPV-16/18 were 3 times more common in dysplastic lesions (OR, 3.29; 95% CI, 1.95-5.53%) and invasive cancers (OR, 3.43; 95% CI, 2.07-5.69%), when compared to normal biopsies. There was no significant difference in HPV-16/18 rates between dysplastic lesions and cancers or between mild, moderate or severe dysplastic lesions. This meta-analysis provides a quantification of the prevalence of HPV types 16/18 in OOPD lesions. These results also support the assumption that HPV-16/18 infection occurs during the early phase of the oral cavity and oropharyngeal carcinogenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Ireland | 1 | <1% |
South Africa | 1 | <1% |
Argentina | 1 | <1% |
United States | 1 | <1% |
Unknown | 102 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 16% |
Researcher | 14 | 13% |
Student > Ph. D. Student | 12 | 11% |
Student > Bachelor | 12 | 11% |
Student > Postgraduate | 9 | 8% |
Other | 31 | 29% |
Unknown | 12 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 62 | 58% |
Agricultural and Biological Sciences | 10 | 9% |
Immunology and Microbiology | 3 | 3% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Computer Science | 2 | 2% |
Other | 8 | 7% |
Unknown | 19 | 18% |