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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
|
|---|---|
| Published in |
Nature Genetics, August 2014
|
| DOI | 10.1038/ng.3079 |
| Pubmed ID | |
| Authors |
Puya Gharahkhani, Kathryn P Burdon, Rhys Fogarty, Shiwani Sharma, Alex W Hewitt, Sarah Martin, Matthew H Law, Katie Cremin, Jessica N Cooke Bailey, Stephanie J Loomis, Louis R Pasquale, Jonathan L Haines, Michael A Hauser, Ananth C Viswanathan, Peter McGuffin, Fotis Topouzis, Paul J Foster, Stuart L Graham, Robert J Casson, Mark Chehade, Andrew J White, Tiger Zhou, Emmanuelle Souzeau, John Landers, Jude T Fitzgerald, Sonja Klebe, Jonathan B Ruddle, Ivan Goldberg, Paul R Healey, Richard A Mills, Jie Jin Wang, Grant W Montgomery, Nicholas G Martin, Graham Radford-Smith, David C Whiteman, Matthew A Brown, Janey L Wiggs, David A Mackey, Paul Mitchell, Stuart MacGregor, Jamie E Craig |
| Abstract |
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian discovery cohort comprising 1,155 cases with advanced POAG and 1,992 controls. We investigated the association of the top SNPs from the discovery stage in two Australian replication cohorts (932 cases and 6,862 controls total) and two US replication cohorts (2,616 cases and 2,634 controls total). Meta-analysis of all cohorts identified three loci newly associated with development of POAG. These loci are located upstream of ABCA1 (rs2472493[G], odds ratio (OR) = 1.31, P = 2.1 × 10(-19)), within AFAP1 (rs4619890[G], OR = 1.20, P = 7.0 × 10(-10)) and within GMDS (rs11969985[G], OR = 1.31, P = 7.7 × 10(-10)). Using RT-PCR and immunolabeling, we show that these genes are expressed within human retina, optic nerve and trabecular meshwork and that ABCA1 and AFAP1 are also expressed in retinal ganglion cells. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 25% |
| Japan | 1 | 13% |
| United States | 1 | 13% |
| Australia | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 2% |
| Mexico | 1 | <1% |
| Nigeria | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 104 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 21% |
| Student > Ph. D. Student | 22 | 20% |
| Student > Bachelor | 12 | 11% |
| Professor | 9 | 8% |
| Student > Master | 9 | 8% |
| Other | 21 | 19% |
| Unknown | 14 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 28% |
| Medicine and Dentistry | 25 | 23% |
| Agricultural and Biological Sciences | 19 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Computer Science | 3 | 3% |
| Other | 10 | 9% |
| Unknown | 19 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2023.
All research outputs
#788,380
of 25,998,826 outputs
Outputs from Nature Genetics
#1,459
of 7,655 outputs
Outputs of similar age
#7,621
of 251,715 outputs
Outputs of similar age from Nature Genetics
#26
of 79 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,715 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.