Title |
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
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Published in |
Nature Genetics, August 2014
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DOI | 10.1038/ng.3079 |
Pubmed ID | |
Authors |
Puya Gharahkhani, Kathryn P Burdon, Rhys Fogarty, Shiwani Sharma, Alex W Hewitt, Sarah Martin, Matthew H Law, Katie Cremin, Jessica N Cooke Bailey, Stephanie J Loomis, Louis R Pasquale, Jonathan L Haines, Michael A Hauser, Ananth C Viswanathan, Peter McGuffin, Fotis Topouzis, Paul J Foster, Stuart L Graham, Robert J Casson, Mark Chehade, Andrew J White, Tiger Zhou, Emmanuelle Souzeau, John Landers, Jude T Fitzgerald, Sonja Klebe, Jonathan B Ruddle, Ivan Goldberg, Paul R Healey, Richard A Mills, Jie Jin Wang, Grant W Montgomery, Nicholas G Martin, Graham Radford-Smith, David C Whiteman, Matthew A Brown, Janey L Wiggs, David A Mackey, Paul Mitchell, Stuart MacGregor, Jamie E Craig |
Abstract |
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian discovery cohort comprising 1,155 cases with advanced POAG and 1,992 controls. We investigated the association of the top SNPs from the discovery stage in two Australian replication cohorts (932 cases and 6,862 controls total) and two US replication cohorts (2,616 cases and 2,634 controls total). Meta-analysis of all cohorts identified three loci newly associated with development of POAG. These loci are located upstream of ABCA1 (rs2472493[G], odds ratio (OR) = 1.31, P = 2.1 × 10(-19)), within AFAP1 (rs4619890[G], OR = 1.20, P = 7.0 × 10(-10)) and within GMDS (rs11969985[G], OR = 1.31, P = 7.7 × 10(-10)). Using RT-PCR and immunolabeling, we show that these genes are expressed within human retina, optic nerve and trabecular meshwork and that ABCA1 and AFAP1 are also expressed in retinal ganglion cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 25% |
Japan | 1 | 13% |
United States | 1 | 13% |
Australia | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Scientists | 2 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 2% |
Mexico | 1 | <1% |
Nigeria | 1 | <1% |
Korea, Republic of | 1 | <1% |
United States | 1 | <1% |
Unknown | 104 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 21% |
Student > Ph. D. Student | 22 | 20% |
Student > Bachelor | 12 | 11% |
Professor | 9 | 8% |
Student > Master | 9 | 8% |
Other | 21 | 19% |
Unknown | 14 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 31 | 28% |
Medicine and Dentistry | 25 | 23% |
Agricultural and Biological Sciences | 19 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Computer Science | 3 | 3% |
Other | 10 | 9% |
Unknown | 19 | 17% |