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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Synthesis and analysis of the anticancer activity of platinum( ii ) complexes incorporating dipyridoquinoxaline variants
|
|---|---|
| Published in |
Dalton Transactions: An International Journal of Inorganic Chemistry, January 2014
|
| DOI | 10.1039/c4dt02133a |
| Pubmed ID | |
| Authors |
Benjamin J. Pages, Feng Li, Paul Wormell, Dale L. Ang, Jack K. Clegg, Cameron J. Kepert, Lawson K. Spare, Supawich Danchaiwijit, Janice R. Aldrich-Wright |
| Abstract |
Eight platinum(II) complexes with anticancer potential have been synthesised and characterised. These complexes are of the type [Pt(I(L))(A(L))](2+), where I(L) is either dipyrido[3,2-f:2',3'-h]quinoxaline (dpq) or 2,3-dimethyl-dpq (23Me2dpq) and A(L) is one of the R,R or S,S isomers of either 1,2-diaminocyclohexane (SS-dach or RR-dach) or 1,2-diaminocyclopentane (SS-dacp or RR-dacp). The CT-DNA binding of these complexes and a series of other complexes were assessed using fluorescent intercalator displacement assays, resulting in unexpected trends in DNA binding affinity. The cytotoxicity of the eight synthesised compounds was determined in the L1210 cell line; the most cytotoxic of these were [Pt(dpq)(SS-dach)]Cl2 and [Pt(dpq)(RR-dach)]Cl2, with IC50 values of 0.19 and 0.80 μM, respectively. The X-ray crystal structure of the complex [Pt(dpq)(SS-dach)](ClO4)2·1.75H2O is also reported. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 28% |
| Student > Bachelor | 4 | 16% |
| Professor | 4 | 16% |
| Student > Master | 3 | 12% |
| Researcher | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 19 | 76% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Unknown | 3 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2014.
All research outputs
#16,311,176
of 25,756,911 outputs
Outputs from Dalton Transactions: An International Journal of Inorganic Chemistry
#6,746
of 21,221 outputs
Outputs of similar age
#189,061
of 321,307 outputs
Outputs of similar age from Dalton Transactions: An International Journal of Inorganic Chemistry
#228
of 1,587 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 21,221 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,307 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,587 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.